Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners

Author(s):Show less -

Vaisberg, Mauro ^[1] ; Paixao, Vitoria ^[1] ; Almeida, Ewin B. ^[1] ; Santos, Juliana M. B. ^[1] ; Foster, Roberta ^[1] ; Rossi, Marcelo ^[1] ; Pithon-Curi, Tania C. ^[2] ; Gorjao, Renata ^[2] ; Momesso, Cesar M. ^[2] ; Andrade, Marilia S. ^[3] ; Araujo, Jose R. ^[4] ; Garcia, Mauricio C. ^[5] ; Cohen, Moises ^[5] ; Perez, Elizabeth C. ^[6] ; Santos-Dias, Alana ^[7] ; Vieira, Rodolfo P. ^{[8, 9, 10, 11]} ; Bachi, Andre L. L. ^{[1, 8]}

Affiliation:Show less -

^[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, BR-04039032 Sao Paulo, SP - Brazil

^[2] Univ Cruzeiro Sul, Inst Phys Act Sci & Sport, BR-01506000 Sao Paulo, SP - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Dept Physiol, BR-04023062 Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Morphol, BR-04023900 Sao Paulo, SP - Brazil

^[5] Fed Univ Sao Paulo UNIFESP, Dept Orthopaed & Traumatol, BR-04024002 Sao Paulo, SP - Brazil

^[6] Paulista Univ UNIP, Environm & Expt Pathol, BR-04043200 Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Childrens Inst, Fac Med, BR-05403000 Sao Paulo, SP - Brazil

^[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Jose Dos Campos, SP - Brazil

^[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-08230030 Sao Paulo, SP - Brazil

^[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, BR-11060001 Santos, SP - Brazil

^[11] Anhembi Morumbi Univ, Sch Med, BR-12230002 Sao Jose Dos Campos, SP - Brazil

• Document type: Journal article
• Source: NUTRIENTS; v. 11, n. 7 JUL 2019.
• Web of Science Citations: 2

Abstract

Background. Although Lactobacillus casei Shirota (LcS) can benefit the immune status, the effects of LcS in the immune/inflammatory responses of marathon runners has never been evaluated. Therefore, here we evaluated the effect of daily ingestion of fermented milk containing or not LcS in the systemic and upper airway immune/inflammatory responses before and after a marathon. Methods. Forty-two male marathon runners ingested a fermented milk containing 40 billion of LcS/day (LcS group, n = 20) or placebo (unfermented milk, n = 22) during 30 days pre-marathon. Immune/inflammatory parameters in nasal mucosa and serum, as well as concentrations of secretory IgA (SIgA) and antimicrobial peptides in saliva, were evaluated before and after fermented milk ingestion, immediately, 72 h, and 14 d post-marathon. Results. Higher proinflammatory cytokine levels in serum and nasal mucosa, and also lower salivary levels of SIgA and antimicrobial peptides, were found immediately post-marathon in the placebo group compared to other time points and to LcS group. In opposite, higher anti-inflammatory levels and reduced neutrophil infiltration on nasal mucosa were found in the LcS group compared to other time points and to the placebo group. Conclusion. For the first time, it is shown that LcS is able to modulate the systemic and airways immune responses post-marathon. (AU)

• FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
• Grantee: Rodolfo de Paula Vieira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/04845-3 - EFFECT OF DAILY INTAKE OF Lactobacillus casei Shirota (LcS) IN THE SYSTEMIC AND UPPER AIRWAYS IMMUNE RESPONSIVENESS OF AMATEUR MARATHON RUNNERS WHO PRESENT UPPER RESEPIRATORY SYMPTOMS
• Grantee: André Luis Lacerda Bachi
• Support Opportunities: Regular Research Grants