Probiotic Supplementation effect on oral microbiota modulation and upper respiratory tract infection in runners

• Grant number: 16/10561-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2017
• End date: March 31, 2021
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal Investigator: José Cesar Rosa Neto
• Grantee: Helena Angélica Pereira Batatinha
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 19/09520-3 - Acute exercise as a strategy to improve the safety and efficacy of donor lymphocyte infusions after allogeneic hematopoietic stem cell transplantation, BE.EP.DR

Abstract

Endurance athletes show increase on upper respiratory tract infection (URTI) development due to a weak immune system. There are lot of bacteria living in the upper respiratory tract those help to maintain body function. They are called microbiota. The exercise training seems to be an important regulator of the microbiota by acting on its relation with immune system and metabolic homeostasis. Probably there is an alteration on microbiota during URTI and high intensity exercise plays a negative rule on this environment increasing the infection. Probiotics supplementation has been investigated as an immunomodulatory agent been able to decrease these infections. However, there is no studies showing the interaction between probiotics supplementation, oral microbiota and URTI development. The aim of this study is to investigate if the microbiota of endurance athletes is changed and whether probiotics supplementation can help to maintain a health microbiota and decrease URTI frequency. Will participate male from 29 to 45 years old runners. They will run a marathon with no supplements, after 7 days of probiotics supplementation and after 30 days of probiotics supplementation. Will be collected salivary and blood samples to measure oral microbiota and immunometabolic parameters (pro and anti-inflammatory cytokines, lipid and insulin profile). A lymphocytes culture will be performed to access cellular function and intercellular mechanism. Hypothesize that athletes have alteration on microbiota and probiotic supplementation improve this parameter.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEREIRA BATATINHA, HELENA ANGELICA; DINIZ, TIEGO APARECIDO; DE SOUZA TEIXEIRA, ALEXANDRE ABILIO; KRUEGER, KARSTEN; ROSA-NETO, JOSE CESAR. Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise. Journal of Cellular Physiology, v. 234, n. 9, p. 14883-14895, SEP 2019. (16/10561-8, 16/01409-8)

BATATINHA, HELENA; TAVARES-SILVA, EDGAR; LEITE, GEOVANA S. F.; RESENDE, AYANE S.; ALBUQUERQUE, JOSE A. T.; ARSLANIAN, CHRISTINA; FOCK, RICARDO A.; LANCHA, JR., ANTONIO H.; LIRA, FABIO S.; KRUEGER, KARSTEN; et al. Probiotic supplementation in marathonists and its impact on lymphocyte population and function after a marathon: a randomized placebo-controlled double-blind study. SCIENTIFIC REPORTS, v. 10, n. 1, NOV 2 2020. (19/09854-9, 16/10561-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BATATINHA, Helena Angélica Pereira. The effects of probiotic supplementation on the immune cells and on upper respiratory tract infection in endurance runners.. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.