Biopharmaceutical and antifungal properties of ellagic acid-cyclodextrin using an in vitro model of invasive candidiasis

Autor(es)

Gontijo, Aline V. L. ^{[1, 2, 3]} ; Sampaio, Aline da G. ^{[2, 3]} ; Koga-Ito, Cristiane Y. ^{[2, 3]} ; Salvador, Marcos J. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Inst Biol, Dept Plant Biol, Campinas, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Environm Engn, Sao Paulo, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Oral Biopathol Grad Program, Sao Jose Campos Inst Sci & Technol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 14, n. 11, p. 957-967, JUL 2019.
• Citações Web of Science: 0

Resumo

Aim: To investigate biopharmaceutical and antifungal properties of pure and complexed ellagic acid. Materials \& methods: Caco-2 cells cultured in a Transwell (R) inserts were infected with Candida albicans to develop an in vitro model. Ellagic acid was complexed with cyclodextrins. Microbial compositions, ellagic acid concentration as function of time and characterization studies of complexes were evaluated. Results: Ellagic acid presented ability to reduce C. albicans invasion, although this was not statistically significant. Its poor water solubility and absorption probably limited this ability. Water solubility was increased after complexation with hydroxypropyl-beta-CD; however, ellagic acid/hydroxypropyl-beta-CD did not improve the antifungal activity. Conclusion: Although ellagic acid presented a promising antifungal activity, its biopharmaceutical properties limit such activity and should be improved. (AU)

• Processo FAPESP: 16/07196-6 - Prospecção de alternativas terapêuticas inovadoras para doenças infecciosas de interesse odontológico: jato de plasma frio sob pressão atmosférica e nanoencapsulado de substância bioativa
• Beneficiário: Cristiane Yumi Koga Ito
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/21207-0 - Avaliação do potencial de aplicação do ácido elágico nanoencapsulado em ciclodextrina no tratamento da candidose bucal
• Beneficiário: Aline da Graça Sampaio
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/09666-4 - Implantação de ensaios in vitro para avaliação das características biofarmacêuticas e da bioatividade de substâncias e de produtos bioativos utilizando modelos celulares de candidíase invasiva
• Beneficiário: Aline Vidal Lacerda Gontijo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado