Pharmacokinetic Aspects of Nanoparticle-in-Matrix Drug Delivery Systems for Oral/Buccal Delivery

Autor(es)

Feitosa, Renata Carvalho ^{[1, 2]} ; Geraldes, Danilo Costa ^{[1, 2]} ; Beraldo-de-Araujo, Viviane Lucia ^[2] ; Ribeiro Costa, Juliana Souza ^{[1, 2]} ; Oliveira-Nascimento, Laura ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Lab Pharmaceut Technol Latef, Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN PHARMACOLOGY; v. 10, SEP 24 2019.
• Citações Web of Science: 0

Resumo

Oral route maintains its predominance among the ones used for drug delivery, especially when medicines are self-administered. If the dosage form is solid, therapy gains in dose precision and drug stability. Yet, some active pharmaceutical substances do not present the required solubility, permeability, or release profile for incorporation into traditional matrices. The combination of nanostructured drugs (nanoparticle {[}NP]) with these matrices is a new and little-explored alternative, which could bring several benefits. Therefore, this review focused on combined delivery systems based on nanostructures to administer drugs by the oral cavity, intended for buccal, sublingual, gastric, or intestinal absorption. We analyzed published NP-in-matrix systems and compared main formulation characteristics, pharmacokinetics, release profiles, and physicochemical stability improvements. The reported formulations are mainly semisolid or solid polymers, with polymeric or lipid NPs and one active pharmaceutical ingredient. Regarding drug specifics, most of them are poorly permeable or greatly metabolized. The few studies with pharmacokinetics showed increased drug bioavailability and, sometimes, a controlled release rate. From our knowledge, the gathered data make up the first focused review of these trendy systems, which we believe will help to gain scientific deepness and future advancements in the field. (AU)

• Processo FAPESP: 19/08281-5 - Desenvolvimento de wafers biopoliméricos para entrega bucal de fármacos nanoestruturados
• Beneficiário: Renata de Carvalho Feitosa
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/19696-1 - Aspectos farmacocinéticos dos sistemas de carreamento de fármacos baseados em nanoparticulas-em-matriz para entrega oral/bucal
• Beneficiário: Laura de Oliveira Nascimento
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo
• Processo FAPESP: 14/14457-5 - Carreadores baseados em lipídios (SLN/NLC e lipossomas com gradiente iônico) como estratégia para aumentar a encapsulação e a potência de anestésicos locais
• Beneficiário: Eneida de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Temático