| Full text | |
| Author(s): |
Feitosa, Renata Carvalho
[1, 2]
;
Geraldes, Danilo Costa
[1, 2]
;
Beraldo-de-Araujo, Viviane Lucia
[2]
;
Ribeiro Costa, Juliana Souza
[1, 2]
;
Oliveira-Nascimento, Laura
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Estadual Campinas, Inst Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Lab Pharmaceut Technol Latef, Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | FRONTIERS IN PHARMACOLOGY; v. 10, SEP 24 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Oral route maintains its predominance among the ones used for drug delivery, especially when medicines are self-administered. If the dosage form is solid, therapy gains in dose precision and drug stability. Yet, some active pharmaceutical substances do not present the required solubility, permeability, or release profile for incorporation into traditional matrices. The combination of nanostructured drugs (nanoparticle {[}NP]) with these matrices is a new and little-explored alternative, which could bring several benefits. Therefore, this review focused on combined delivery systems based on nanostructures to administer drugs by the oral cavity, intended for buccal, sublingual, gastric, or intestinal absorption. We analyzed published NP-in-matrix systems and compared main formulation characteristics, pharmacokinetics, release profiles, and physicochemical stability improvements. The reported formulations are mainly semisolid or solid polymers, with polymeric or lipid NPs and one active pharmaceutical ingredient. Regarding drug specifics, most of them are poorly permeable or greatly metabolized. The few studies with pharmacokinetics showed increased drug bioavailability and, sometimes, a controlled release rate. From our knowledge, the gathered data make up the first focused review of these trendy systems, which we believe will help to gain scientific deepness and future advancements in the field. (AU) | |
| FAPESP's process: | 19/08281-5 - Development of biopolymeric wafers for buccal delivery of nanostructured drugs |
| Grantee: | Renata de Carvalho Feitosa |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics |
| Grantee: | Eneida de Paula |
| Support Opportunities: | Research Projects - Thematic Grants |