A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale

Autor(es)

Seva, Anaia da Paixao ^[1] ; Martins, Thiago Fernandes ^[2] ; Munoz-Leal, Sebastian ^[2] ; Rodrigues, Ana Carla ^[3] ; Pinter, Adriano ^[4] ; Luz, Hermes R. ^[5] ; Angerami, Rodrigo N. ^[6] ; Labruna, Marcelo B. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Santa Cruz, Ilheus, BA - Brazil

^[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, Sao Paulo, SP - Brazil

^[3] Univ Estado Mato Grosso, Campus Nova Xavantina, Nova Xavantina, MT - Brazil

^[4] Superintendencia Controle Endemias Estado Sao Pau, Sao Paulo, SP - Brazil

^[5] Univ Fed Maranhao, Dept Patol, RENORBIO, Sao Luis, MA - Brazil

^[6] Univ Estadual Campinas, Hosp Clin, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PARASITES & VECTORS; v. 12, n. 1 OCT 11 2019.
• Citações Web of Science: 0

Resumo

Background Rickettsia parkeri strain Atlantic rainforest has emerged in Brazil during the last 10 years, with three laboratory-confirmed human cases. While these cases were epidemiologically associated with the tick Amblyomma ovale, in none of them the tick specimens that bit the patients could be identified. Results We report a clinical case of spotted fever rickettsiosis that was acquired in an Atlantic forest area in Bahia state, northeast Brazil. The case was determined to be caused by R. parkeri strain Atlantic rainforest, based on molecular analysis of the crust removed from the tick bite site (inoculation eschar) of the patients' skin. DNA extracted from the crust yielded partial sequences of three rickettsial genes (gltA, ompA and ompB), which were 99-100% identical to R. parkeri strain Atlantic rainforest. The tick specimen that was attached to patient skin was identified as a female of A. ovale. Conclusions We report the fourth confirmed case of spotted fever rickettsiosis caused by R. parkeri strain Atlantic rainforest, providing to our knowledge for the first time, direct evidence of R. parkeri strain Atlantic rainforest transmission by A. ovale. (AU)

• Processo FAPESP: 18/02521-1 - Pesquisa de espiroquetas do grupo da febre recorrente (Spirochaetaceae: Borrelia) em carrapatos do gênero Ornithodoros (Acari: Argasidae) parasitas de humanos no Brasil
• Beneficiário: Sebastián Alejandro Munoz Leal
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado