Natural deep eutectic solvents and aqueous solutions as an alternative extraction media for propolis

Autor(es)

Funari, Cristiano Soleo ; Sutton, Adam T. ^[1] ; Carneiro, Renato Lajarim ^[2] ; Fraige, Karina ^[3] ; Cavalheiro, Alberto Jose ^[3] ; Bolzani, Vanderlan da Silva ^[3] ; Hilder, Emily F. ^[1] ; Dario Arrua, R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ South Australia UniSA, Future Ind Inst, Adelaide, SA - Australia

^[2] Fed Univ Sao Carlos UFSCar, Dept Chem, Sao Carlos, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Food Research International; v. 125, NOV 2019.
• Citações Web of Science: 1

Resumo

Ethanolic extracts of propolis are consumed for their health benefits even though direct consumption of alcoholic extracts is not always ideal. Natural Deep Eutectic Solvents (NADES) can potentially extract similar compounds as alcoholic extracts while being better for direct consumption. Therefore, in this work alternative solvents for the extraction of green propolis including its biomarker artepillin C were examined. Sixteen NADES made from low toxicity chemicals, including the essential amino acid L-lysine, were explored along with twelve individual NADES components and honey, which showed similar physical-chemical properties to NADES. At 50 degrees C NADES made from choline chloride-propylene glycol or lactic acid proved to be equal or better than the benchmark EtOH:Water 7:3 (v/v). Alternatively, aqueous t.-lysine appeared as a potential solvent for the preparation of aqueous propolis extracts. From these findings NADES, honey and aqueous L-lysine solutions all demonstrated the potential to replace ethanol or water for extracting green propolis. (AU)

• Processo FAPESP: 17/06216-6 - Desenvolvimento de metodologias analíticas verdes na busca por compostos orgânicos de alto valor agregado em resíduos agrícolas
• Beneficiário: Cristiano Soleo de Funari
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 13/15086-8 - Aplicações da metabolômica e proteômica na busca por novas substâncias biologicamente ativas em espécies da família Malpighiaceae
• Beneficiário: Karina Fraige Baraco
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/50009-2 - Greening sample preparation of complex matrices by using natural deep eutectic solvents (NADES) together with porous polymeric adsorbents for subsequent analyses by liquid chromatography (LC) and nuclear magnetic resonance (NMR)
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Regular