Análise comparativa de neurônios derivados de células-tronco pluripotentes induzid...
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Texto completo | |
Autor(es): |
Número total de Autores: 4
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Afiliação do(s) autor(es): | [1] V, Univ Sao Paulo, Natl Lab Embryon Stem Cells LaNCE, Dept Genet & Evolutionary Biol, Biosci Inst, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo HC FMUSP, Movement Disorders Clin, Hosp Clin, Fac Med, Div Neurol, Sao Paulo - Brazil
Número total de Afiliações: 2
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Tipo de documento: | Artigo Científico |
Fonte: | STEM CELL RESEARCH; v. 39, AUG 2019. |
Citações Web of Science: | 0 |
Resumo | |
We describe the generation and characterization of hiPSC lines of one type 1-Gaucher disease patient with Parkinson's disease and two unrelated Parkinson's disease patients heterozygous for GBA mutations. Human iPSCs were derived from lymphocytes reprogrammed with Sendai virus carrying the reprogramming factors OCT3/4, SOX2, KLF4 and MYC. The hiPSC lines were characterized according to established criteria, and retained the original GBA mutations found in the respective patients. (AU) | |
Processo FAPESP: | 13/08135-2 - CTC - Centro de Terapia Celular |
Beneficiário: | Dimas Tadeu Covas |
Linha de fomento: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |