Generation of three human induced pluripotent stem cell (hiPSC) lines derived from one Gaucher disease patient with Parkinson's disease and two unrelated Parkinson's disease patients with GBA mutations

Tofoli, Fabiano A.; Chien, Hsin Fen; Barbosa, Egberto Reis; Pereira, V, Lygia

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Generation of three human induced pluripotent stem cell (hiPSC) lines derived from one Gaucher disease patient with Parkinson's disease and two unrelated Parkinson's disease patients with GBA mutations

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Author(s):	Tofoli, Fabiano A. ^[1] ; Chien, Hsin Fen ^[2] ; Barbosa, Egberto Reis ^[2] ; Pereira, V, Lygia Total Authors: 4
Affiliation:	^[1] V, Univ Sao Paulo, Natl Lab Embryon Stem Cells LaNCE, Dept Genet & Evolutionary Biol, Biosci Inst, BR-05508900 Sao Paulo, SP - Brazil ^[2] Univ Sao Paulo HC FMUSP, Movement Disorders Clin, Hosp Clin, Fac Med, Div Neurol, Sao Paulo - Brazil Total Affiliations: 2
Document type:	Journal article
Source:	STEM CELL RESEARCH; v. 39, AUG 2019.
Web of Science Citations:	0
Abstract
We describe the generation and characterization of hiPSC lines of one type 1-Gaucher disease patient with Parkinson's disease and two unrelated Parkinson's disease patients heterozygous for GBA mutations. Human iPSCs were derived from lymphocytes reprogrammed with Sendai virus carrying the reprogramming factors OCT3/4, SOX2, KLF4 and MYC. The hiPSC lines were characterized according to established criteria, and retained the original GBA mutations found in the respective patients. (AU)

FAPESP's process:	13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:	Dimas Tadeu Covas
Support Opportunities:	Research Grants - Research, Innovation and Dissemination Centers - RIDC

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