Human Antigen Leucocyte (HLA)-G and HLA-E are differentially expressed in pancreatic disorders

Autor(es)

Bertol, Bruna Cristina ^[1] ; Dias, Fabricio Cesar ^[2] ; da Silva, Deisy Mara ^[3] ; Zambelli Ramalho, Leandra Naira ^[3] ; Donadi, Eduardo Antonio ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Basic & Appl Inununol, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Div Clin Immunol, Dept Med, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, 3900 Bandeirantes Ave, BR-14049900 Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HUMAN IMMUNOLOGY; v. 80, n. 11, p. 948-954, NOV 2019.
• Citações Web of Science: 0

Resumo

Background: Little information is available regarding the expression of the immunomodulatory Human Leukocyte Antigen (HLA)-G and -E molecules in pancreatic disorders. Aim: To analyze HLA-G and -E expression in specimens of alcoholic chronic pancreatitis (ACP), idiopathic chronic pancreatitis (ICP), type 1 (T1D) and type 2 diabetes (T2D) and in histologically normal pancreas (HNP). Methods: HLA-G and -E expression (ACP = 30, ICP = 10, T1D = 10, T2D = 30 and HNP = 20) was evaluated by immunohistochemistry in three different areas (acini, islets and inflammatory infiltrate). Results: Acini and islets from HNP specimens exhibited higher HLA-G and -E expression compared to corresponding areas from all other patient groups. In inflammatory infiltrate, HLA-G and -E expression was observed only among the pancreatic disorders. We observed higher HLA-G and -E expression in acini from T2D compared to ACP, as well as higher HLA-G expression compared to ICP. Conclusion: The decreased expression of HLA-G and -E in islets and acini together with the expression of these molecules in the inflammatory infiltrating cells were shared features among chronic inflammatory and auto immune pancreatic disorders evaluated in this study, possibly reflecting tissue damage. (AU)

• Processo FAPESP: 15/26556-0 - Associação dos genes HLA-G, BRAF e TERT com a malignidade do carcinoma papilífero de tireoide
• Beneficiário: Bruna Cristina Bertol
• Modalidade de apoio: Bolsas no Brasil - Doutorado