NADPH Producing Enzymes as Promising Drug Targets for Chagas Disease

Autor(es)

Cordeiro, Artur T.

• Tipo de documento: Artigo de Revisão
• Fonte: Current Medicinal Chemistry; v. 26, n. 36, p. 6564-6571, 2019.
• Citações Web of Science: 1

Resumo

Reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH) is a cofactor used in different anabolic reactions, such as lipid and nucleic acid synthesis, and for oxidative stress defense. NADPH is essential for parasite growth and viability. In trypanosomatid parasites, NADPH is supplied by the oxidative branch of the pentose phosphate pathway and by enzymes associated with the citric acid cycle. The present article will review recent achievements that suggest glucose-6-phosphate dehydrogenase and the cytosolic isoform of the malic enzyme as promising drug targets for the discovery of new drugs against nypanosoma cruzi and T. brucei. Topics involving an alternative strategy in accelerating T. cruzi drug-target validation and the concept of drug-target classification will also be revisited. (AU)

• Processo FAPESP: 16/14271-4 - Aperfeiçoamento dos inibidores da enzima G6PDH para desenvolvimento de fármacos contra Chagas
• Beneficiário: Artur Torres Cordeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular