Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality

Autor(es)

De Carvalho, Flavia G. ^{[1, 2]} ; Justice, Jamie N. ^[3] ; de Freitas, Ellen C. ^[1] ; Kershaw, Erin E. ^[4] ; Sparks, Lauren M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ave Bandeirantes 3900, BR-14040907 Ribeirao Preto, SP - Brazil

^[2] Advent Hlth, Translat Res Inst, 301 East Princeton St, Orlando, FL 32804 - USA

^[3] Wake Forest Sch Med, Internal Med Sect Gerontol & Geriatr Med, 1 Med Ctr Blvd, Winston Salem, NC 27157 - USA

^[4] Univ Pittsburgh, Dept Med, Div Endocrinol & Metab, 930 Scaife Hall, Pittsburgh, PA 15260 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRIENTS; v. 11, n. 11 NOV 2019.
• Citações Web of Science: 0

Resumo

The interplay between adipose tissue and skeletal muscle and the impact on mobility and aging remain enigmatic. The progressive decline in mobility promoted by aging has been previously attributed to the loss of skeletal mass and function and more recently linked to changes in body fat composition and quantity. Regardless of body size, visceral and intermuscular adipose depots increase with aging and are associated with adverse health outcomes. However, the quality of adipose tissue, in particular abdominal subcutaneous as it is the largest depot, likely plays a significant role in aging outcomes, such as mobility decline, though its communication with other tissues such as skeletal muscle. In this review, we discuss the age-associated development of a pro-inflammatory profile, cellular senescence, and metabolic inflexibility in abdominal subcutaneous adipose tissue. Collectively, these facets of adipose tissue quality influence its secretory profile and crosstalk with skeletal muscle and likely contribute to the development of muscle atrophy and disability. Therefore, the identification of the key structural and functional components of adipose tissue quality-including necrosis, senescence, inflammation, self-renewal, metabolic flexibility-and adipose tissue-secreted proteins that influence mobility via direct effects on skeletal muscle are necessary to prevent morbidity/mortality in the aging population. (AU)

• Processo FAPESP: 17/08036-5 - Efeitos da suplementação de taurina associada ou não a prática de exercício concorrente sobre a função mitocondrial, gasto energético e perfil inflamatório de mulheres obesas
• Beneficiário: Flávia Giolo De Carvalho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/17711-0 - Regulação epigenômica do padrão de gordura em mulheres (maçã vs. pêra)
• Beneficiário: Flávia Giolo De Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado