Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G

Autor(es)

Pupin, Rafael Rovatti ^{[1, 2]} ; Foguel, Marcos Vinicius ^{[3, 1, 2]} ; Goncalves, Luis Moreira ^[4] ; Sotomayor, Maria del Pilar T. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Inst Chem, Dept Analyt Chem, UNESP, Araraquara, SP - Brazil

^[2] UNESP, Natl Inst Alternat Technol Detect Toxicol Evaluat, Inst Chem, Araraquara, SP - Brazil

^[3] Univ Cent Florida, Dept Chem, Orlando, FL 32816 - USA

^[4] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Polymer Science; v. 137, n. 13 APR 5 2020.
• Citações Web of Science: 11

Resumo

Some of the most important life-saving medications are beta-lactam antibiotics (such as Penicillin G). However, these medicines have not adequately been discharged into the environment; penicillin residues offer health risks and enhance the development of resistances. Thus, its selective separation from complex matrices is a challenge worth tackling. A novel strategy of synthesis, by photopolymerization, was applied to develop magnetic molecular imprinted polymers (mag-MIPs) aiming the recognition of penicillin G (also known as benzylpenicillin). Photopolymerization, when compared with the more common thermopolymerization, has the advantage of occurring at lower temperatures, which prevents analyte degradation. The Mag-MIP presented higher surface area than the conventional MIP and good adsorption capacity of the analyte while maintaining its selectivity. The synthesized material was characterized by X-ray diffraction, showing that the magnetite nanoparticles were formed and the MIP polymerization on their surface was performed, once the material was amorphous. Furthermore, the pore formation was evaluated by BET, indicating a high surface area (832 m(2) g(-1)) and large pore volume (0.80 cm(3) g(-1)) in the mag-MIP compared to the magnetic non-imprinted polymer (mag-NIP: 147 m(2) g(-1) and 0.33 cm(3) g(-1)). (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48496. (AU)

• Processo FAPESP: 18/14425-7 - Um novo rumo sinérgico para a microextração por difusão gasosa (GDME) fazendo uso de polímeros com impressão molecular (MIPs)
• Beneficiário: Luís Francisco Moreira Gonçalves
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/06926-0 - Desenvolvimento e aplicação de novos sensores químicos nanoestruturados e aplicação de novos sensores químicos nanoestruturados baseados em polímeros biomiméticos
• Beneficiário: Maria Del Pilar Taboada Sotomayor
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
• Processo FAPESP: 12/14181-4 - Síntese de nanopartículas magnéticas modificadas com polímeros biomiméticos para Penicilina-G
• Beneficiário: Rafael Rovatti Pupin
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica