Magnetic molecularly imprinted polymers obtained by photopolymerization for selective recognition of penicillin G

Author(s)

Pupin, Rafael Rovatti ^{[1, 2]} ; Foguel, Marcos Vinicius ^{[3, 1, 2]} ; Goncalves, Luis Moreira ^[4] ; Sotomayor, Maria del Pilar T. ^{[1, 2]}

Affiliation

^[1] Univ Estadual Paulista, Inst Chem, Dept Analyt Chem, UNESP, Araraquara, SP - Brazil

^[2] UNESP, Natl Inst Alternat Technol Detect Toxicol Evaluat, Inst Chem, Araraquara, SP - Brazil

^[3] Univ Cent Florida, Dept Chem, Orlando, FL 32816 - USA

^[4] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Journal of Applied Polymer Science; v. 137, n. 13 APR 5 2020.
• Web of Science Citations: 11

Abstract

Some of the most important life-saving medications are beta-lactam antibiotics (such as Penicillin G). However, these medicines have not adequately been discharged into the environment; penicillin residues offer health risks and enhance the development of resistances. Thus, its selective separation from complex matrices is a challenge worth tackling. A novel strategy of synthesis, by photopolymerization, was applied to develop magnetic molecular imprinted polymers (mag-MIPs) aiming the recognition of penicillin G (also known as benzylpenicillin). Photopolymerization, when compared with the more common thermopolymerization, has the advantage of occurring at lower temperatures, which prevents analyte degradation. The Mag-MIP presented higher surface area than the conventional MIP and good adsorption capacity of the analyte while maintaining its selectivity. The synthesized material was characterized by X-ray diffraction, showing that the magnetite nanoparticles were formed and the MIP polymerization on their surface was performed, once the material was amorphous. Furthermore, the pore formation was evaluated by BET, indicating a high surface area (832 m(2) g(-1)) and large pore volume (0.80 cm(3) g(-1)) in the mag-MIP compared to the magnetic non-imprinted polymer (mag-NIP: 147 m(2) g(-1) and 0.33 cm(3) g(-1)). (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48496. (AU)

• FAPESP's process: 18/14425-7 - A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs)
• Grantee: Luís Francisco Moreira Gonçalves
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/06926-0 - Development and application of new nanostructured chemical sensors and applications of new nanostructured chemical sensors based on biomimetic polymers
• Grantee: Maria Del Pilar Taboada Sotomayor
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• FAPESP's process: 12/14181-4 - Synthesis of magnetic nanoparticles modified with biomimetic polymer for Penicillin-G
• Grantee: Rafael Rovatti Pupin
• Support Opportunities: Scholarships in Brazil - Scientific Initiation