| Texto completo | |
| Autor(es): |
Alencar Bezerra, Taliana Kenia
[1]
;
Jocelino Gomes de Lacerda, Jose Thalles
[2]
;
Salu, Bruno Ramos
[3]
;
Vilela Oliva, Maria Luiza
[3]
;
Juliano, Maria Aparecida
[2]
;
Pacheco, Maria Teresa Bertoldo
[4]
;
Madruga, Marta Suely
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Fed Paraiba, Technol Ctr, Dept Food Engn, Postgrad Program Food Sci & Technol, BR-58051900 Joao Pessoa, Paraiba - Brazil
[2] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biochem, Sao Paulo, SP - Brazil
[4] Ctr Food Sci & Qual, Food Technol Inst ITAL, Campinas, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF MEDICINAL FOOD; v. 22, n. 12 DEC 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Peptides from protein hydrolysate of a mixture of chicken combs and wattles (CCWs) were obtained through enzymatic hydrolysis, and their anticoagulant and inhibitory effects on angiotensin I-converting enzyme (ACE) were investigated. The protein hydrolysate exhibited anticoagulant capacity by the intrinsic pathway (activated partial thromboplastin time) and potent ACE-inhibitory activity. The peptides were sequenced by LC-MS to identify those with higher inhibitory potential. From the pool of sequenced peptides, the following three peptides were selected and synthesized based on their low molecular weight and the presence of amino acids with ACE-inhibitory potential at the C-terminus: peptide I (APGLPGPR), peptide II (Piro-GPPGPT), and peptide III (FPGPPGP). Peptide III (FPGPPGP) showed the highest ACE-inhibitory capacity among the peptides selected. In conclusion, a peptide (FPGPPGP) of unknown sequence was identified as having potent ACE-inhibitory capacity. This peptide originated from unconventional hydrolysates from poultry slaughter waste, including combs and wattles. (AU) | |
| Processo FAPESP: | 18/13588-0 - EMU concedido no processo 2012/50191-4: espectrômetro de massas IMPACT II da Bruker |
| Beneficiário: | Maria Aparecida Juliano |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 12/50191-4 - Síntese, estudo cinético e aplicações de substratos e inibidores de enzimas proteolíticas |
| Beneficiário: | Maria Aparecida Juliano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |