FOXP3+and CD25+cells are reduced in patients with stage IV, grade C periodontitis: A comparative clinical study

Autor(es)

da Motta, Raphael J. G. ^[1] ; Almeida, Luciana Yamamoto ^[2] ; Villafuerte, Kelly R. V. ^[3] ; Ribeiro-Silva, Alfredo ^[4] ; Leon, Jorge E. ^[5] ; Tirapelli, Camila ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Dept Dent Mat & Prosthodont, Integrated Dent Clin, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch FM RP USP, Dept Clin Med, Haematol Div, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP USP, Dept Pathol, Ribeirao Preto - Brazil

^[5] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Oral Pathol, Dept Stomatol Publ Oral Hlth & Forens Dent, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PERIODONTAL RESEARCH; v. 55, n. 3 DEC 2019.
• Citações Web of Science: 0

Resumo

Background and Objective Some studies suggest that regulatory T cells (Tregs) have suppressive effects on inflammatory osteolysis. The aim of this study was to evaluate Treg immunomarkers in periodontitis-affected tissues from patients with periodontitis and clinically healthy gingiva (control). Material and Methods The presence and distribution of positive cells for CD4, CD25 and FOXP3 (Treg immunomarkers) in periodontitis-affected tissues (epithelium and lamina propria) of 30 patients (ten per group) with a diagnosis of stage IV, grade C periodontitis (IV-C), stage III, grade B periodontitis (III-B) and the control were evaluated. A two-way ANOVA followed by Fisher's LSD test was used to demonstrate differences between the groups and immunomarkers; Student's t test was used to demonstrate differences between the epithelium and the lamina propria. Results Both IV-C and III-B periodontitis presented a significantly high proportion of immune-stained cells for all immunomarkers when compared to the control group. Notably, CD25+ and FOXP3+ cells were detected in a significantly higher number in III-B than IV-C periodontitis (P < .05). Conclusion Our results suggest the participation of Tregs on the osteoimmunological mechanisms in IV-C and III-B periodontitis patients, notably contributing to strategies for alveolar bone regeneration in clinical treatment decisions. (AU)

• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
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• Modalidade de apoio: Auxílio à Pesquisa - Regular
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• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
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