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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

FOXP3+and CD25+cells are reduced in patients with stage IV, grade C periodontitis: A comparative clinical study

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Author(s):
da Motta, Raphael J. G. [1] ; Almeida, Luciana Yamamoto [2] ; Villafuerte, Kelly R. V. [3] ; Ribeiro-Silva, Alfredo [4] ; Leon, Jorge E. [5] ; Tirapelli, Camila [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Dept Dent Mat & Prosthodont, Integrated Dent Clin, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch FM RP USP, Dept Clin Med, Haematol Div, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch FMRP USP, Dept Pathol, Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Oral Pathol, Dept Stomatol Publ Oral Hlth & Forens Dent, Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF PERIODONTAL RESEARCH; v. 55, n. 3 DEC 2019.
Web of Science Citations: 0
Abstract

Background and Objective Some studies suggest that regulatory T cells (Tregs) have suppressive effects on inflammatory osteolysis. The aim of this study was to evaluate Treg immunomarkers in periodontitis-affected tissues from patients with periodontitis and clinically healthy gingiva (control). Material and Methods The presence and distribution of positive cells for CD4, CD25 and FOXP3 (Treg immunomarkers) in periodontitis-affected tissues (epithelium and lamina propria) of 30 patients (ten per group) with a diagnosis of stage IV, grade C periodontitis (IV-C), stage III, grade B periodontitis (III-B) and the control were evaluated. A two-way ANOVA followed by Fisher's LSD test was used to demonstrate differences between the groups and immunomarkers; Student's t test was used to demonstrate differences between the epithelium and the lamina propria. Results Both IV-C and III-B periodontitis presented a significantly high proportion of immune-stained cells for all immunomarkers when compared to the control group. Notably, CD25+ and FOXP3+ cells were detected in a significantly higher number in III-B than IV-C periodontitis (P < .05). Conclusion Our results suggest the participation of Tregs on the osteoimmunological mechanisms in IV-C and III-B periodontitis patients, notably contributing to strategies for alveolar bone regeneration in clinical treatment decisions. (AU)

FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
Grantee:Jorge Esquiche León
Support type: Regular Research Grants
FAPESP's process: 13/08589-3 - Immunohistochemical characterization and distribution of dendritic cells and cytotoxic lymphocytes in the periodontal disease
Grantee:Raphael Jurca Gonçalves da Motta
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies.
Grantee:Luciana Yamamoto de Almeida
Support type: Scholarships in Brazil - Post-Doctorate