da Motta, Raphael J. G.
Almeida, Luciana Yamamoto
Villafuerte, Kelly R. V.
Leon, Jorge E.
Total Authors: 6
 Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Dept Dent Mat & Prosthodont, Integrated Dent Clin, Ribeirao Preto - Brazil
 Univ Sao Paulo, Ribeirao Preto Med Sch FM RP USP, Dept Clin Med, Haematol Div, Ribeirao Preto - Brazil
 Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto - Brazil
 Univ Sao Paulo, Ribeirao Preto Med Sch FMRP USP, Dept Pathol, Ribeirao Preto - Brazil
 Univ Sao Paulo, Sch Dent Ribeirao Preto FORP USP, Oral Pathol, Dept Stomatol Publ Oral Hlth & Forens Dent, Ribeirao Preto, SP - Brazil
Total Affiliations: 5
JOURNAL OF PERIODONTAL RESEARCH;
Web of Science Citations:
Background and Objective Some studies suggest that regulatory T cells (Tregs) have suppressive effects on inflammatory osteolysis. The aim of this study was to evaluate Treg immunomarkers in periodontitis-affected tissues from patients with periodontitis and clinically healthy gingiva (control). Material and Methods The presence and distribution of positive cells for CD4, CD25 and FOXP3 (Treg immunomarkers) in periodontitis-affected tissues (epithelium and lamina propria) of 30 patients (ten per group) with a diagnosis of stage IV, grade C periodontitis (IV-C), stage III, grade B periodontitis (III-B) and the control were evaluated. A two-way ANOVA followed by Fisher's LSD test was used to demonstrate differences between the groups and immunomarkers; Student's t test was used to demonstrate differences between the epithelium and the lamina propria. Results Both IV-C and III-B periodontitis presented a significantly high proportion of immune-stained cells for all immunomarkers when compared to the control group. Notably, CD25+ and FOXP3+ cells were detected in a significantly higher number in III-B than IV-C periodontitis (P < .05). Conclusion Our results suggest the participation of Tregs on the osteoimmunological mechanisms in IV-C and III-B periodontitis patients, notably contributing to strategies for alveolar bone regeneration in clinical treatment decisions. (AU)