| Texto completo | |
| Autor(es): |
Castelletto, Valeria
[1]
;
Edwards-Gayle, Charlotte J. C.
[1]
;
Hamley, Ian W.
[1]
;
Barrett, Glyn
[2]
;
Seitsonen, Jani
[3]
;
Ruokolainen, Janne
[3]
;
de Mello, Lucas Rodrigues
[4]
;
da Silva, Emerson Rodrigo
[4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks - England
[2] Univ Reading, Sch Biol Sci, Reading RG6 6UR, Berks - England
[3] Aalto Univ, Nanomicroscopy Ctr, Puumiehenkuja 2, FIN-02150 Espoo - Finland
[4] Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMICAL COMMUNICATIONS; v. 56, n. 4, p. 615-618, JAN 14 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3 `-5 `)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR. (AU) | |
| Processo FAPESP: | 16/24409-3 - Peptídeos Penetrantes de Células para Transporte de DNA plasmídial e microRNA: da Estrutura Nanoscópica a Entrega de Genes. |
| Beneficiário: | Emerson Rodrigo da Silva |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |