Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria

Autor(es)

Castelletto, Valeria ^[1] ; Edwards-Gayle, Charlotte J. C. ^[1] ; Hamley, Ian W. ^[1] ; Barrett, Glyn ^[2] ; Seitsonen, Jani ^[3] ; Ruokolainen, Janne ^[3] ; de Mello, Lucas Rodrigues ^[4] ; da Silva, Emerson Rodrigo ^[4]

Afiliação do(s) autor(es)

^[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks - England

^[2] Univ Reading, Sch Biol Sci, Reading RG6 6UR, Berks - England

^[3] Aalto Univ, Nanomicroscopy Ctr, Puumiehenkuja 2, FIN-02150 Espoo - Finland

^[4] Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL COMMUNICATIONS; v. 56, n. 4, p. 615-618, JAN 14 2020.
• Citações Web of Science: 0

Resumo

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3 `-5 `)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR. (AU)

• Processo FAPESP: 16/24409-3 - Peptídeos Penetrantes de Células para Transporte de DNA plasmídial e microRNA: da Estrutura Nanoscópica a Entrega de Genes.
• Beneficiário: Emerson Rodrigo da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular