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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria

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Author(s):
Castelletto, Valeria [1] ; Edwards-Gayle, Charlotte J. C. [1] ; Hamley, Ian W. [1] ; Barrett, Glyn [2] ; Seitsonen, Jani [3] ; Ruokolainen, Janne [3] ; de Mello, Lucas Rodrigues [4] ; da Silva, Emerson Rodrigo [4]
Total Authors: 8
Affiliation:
[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks - England
[2] Univ Reading, Sch Biol Sci, Reading RG6 6UR, Berks - England
[3] Aalto Univ, Nanomicroscopy Ctr, Puumiehenkuja 2, FIN-02150 Espoo - Finland
[4] Univ Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CHEMICAL COMMUNICATIONS; v. 56, n. 4, p. 615-618, JAN 14 2020.
Web of Science Citations: 0
Abstract

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(3 `-5 `)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR. (AU)

FAPESP's process: 16/24409-3 - Cell-Penetrating Peptides for Transport of Plasmid DNA and microRNA: from Nanoscopic Structure to Gene Delivery.
Grantee:Emerson Rodrigo da Silva
Support Opportunities: Regular Research Grants