Residence Time Distribution of a Capillary Microreactor Used for Pharmaceutical Synthesis

Autor(es)

Siguemoto, Erica S. ^[1] ; Leite Reche, Leandro ^[2] ; Gut, Jorge A. W. ^{[1, 3]} ; Palma, Mauri S. A. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Chem Engn, Ave Prof Luciano Gualberto 380, BR-05508010 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, FoRC Food Res Ctr, Rua Lago 250, BR-05508080 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL ENGINEERING & TECHNOLOGY; v. 43, n. 3 JAN 2020.
• Citações Web of Science: 0

Resumo

The main drivers for application of small-scale reactors in the pharmaceutical industry are the possibility of rapid synthesis and screening of novel drugs as well as the readiness of the scale-up. The characterization of fluid flow pattern was performed through step-up and step-down residence time distribution experiments using a tracer at six different flow rates. Four single-parameter models were considered for representing deviations from ideal plug flow and ideal laminar flow in tubes. The model that provided the best results was the axial dispersion model and the Peclet and Reynolds numbers could be well correlated. Obtained Peclet values from 44 to 244 were close to Pe > 100, in which axial dispersion can be neglected and the reactor can be considered as plug flow reactor. (AU)

• Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
• Beneficiário: Bernadette Dora Gombossy de Melo Franco
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 17/12830-9 - Síntese da Pioglitazona, Rosiglitazona e Lobeglitazona em fluxo contínuo em microrreatores capilares
• Beneficiário: Mauri Sergio Alves Palma
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/07757-2 - Microreatores na síntese de fármacos
• Beneficiário: Mauri Sergio Alves Palma
• Modalidade de apoio: Auxílio à Pesquisa - Regular