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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Residence Time Distribution of a Capillary Microreactor Used for Pharmaceutical Synthesis

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Author(s):
Siguemoto, Erica S. [1] ; Leite Reche, Leandro [2] ; Gut, Jorge A. W. [1, 3] ; Palma, Mauri S. A. [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Chem Engn, Ave Prof Luciano Gualberto 380, BR-05508010 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo - Brazil
[3] Univ Sao Paulo, FoRC Food Res Ctr, Rua Lago 250, BR-05508080 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CHEMICAL ENGINEERING & TECHNOLOGY; v. 43, n. 3 JAN 2020.
Web of Science Citations: 0
Abstract

The main drivers for application of small-scale reactors in the pharmaceutical industry are the possibility of rapid synthesis and screening of novel drugs as well as the readiness of the scale-up. The characterization of fluid flow pattern was performed through step-up and step-down residence time distribution experiments using a tracer at six different flow rates. Four single-parameter models were considered for representing deviations from ideal plug flow and ideal laminar flow in tubes. The model that provided the best results was the axial dispersion model and the Peclet and Reynolds numbers could be well correlated. Obtained Peclet values from 44 to 244 were close to Pe > 100, in which axial dispersion can be neglected and the reactor can be considered as plug flow reactor. (AU)

FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 17/12830-9 - Synthesis of Pioglitazone, Rosiglitazone and Lobeglitazone in continuous flow in capillary microreactors
Grantee:Mauri Sergio Alves Palma
Support type: Regular Research Grants
FAPESP's process: 14/07757-2 - Micro-reactors in the synthesis of pharmaceuticals
Grantee:Mauri Sergio Alves Palma
Support type: Regular Research Grants