Transposition of the synthesis of Pioglitazone from the batch process to flow proc...
| Full text | |
| Author(s): |
Siguemoto, Erica S.
[1]
;
Leite Reche, Leandro
[2]
;
Gut, Jorge A. W.
[1, 3]
;
Palma, Mauri S. A.
[2]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Dept Chem Engn, Ave Prof Luciano Gualberto 380, BR-05508010 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Biochem & Pharmaceut Technol, Ave Prof Lineu Prestes 580, BR-05508000 Sao Paulo - Brazil
[3] Univ Sao Paulo, FoRC Food Res Ctr, Rua Lago 250, BR-05508080 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | CHEMICAL ENGINEERING & TECHNOLOGY; v. 43, n. 3 JAN 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The main drivers for application of small-scale reactors in the pharmaceutical industry are the possibility of rapid synthesis and screening of novel drugs as well as the readiness of the scale-up. The characterization of fluid flow pattern was performed through step-up and step-down residence time distribution experiments using a tracer at six different flow rates. Four single-parameter models were considered for representing deviations from ideal plug flow and ideal laminar flow in tubes. The model that provided the best results was the axial dispersion model and the Peclet and Reynolds numbers could be well correlated. Obtained Peclet values from 44 to 244 were close to Pe > 100, in which axial dispersion can be neglected and the reactor can be considered as plug flow reactor. (AU) | |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 17/12830-9 - Synthesis of Pioglitazone, Rosiglitazone and Lobeglitazone in continuous flow in capillary microreactors |
| Grantee: | Mauri Sergio Alves Palma |
| Support type: | Regular Research Grants |
| FAPESP's process: | 14/07757-2 - Micro-reactors in the synthesis of pharmaceuticals |
| Grantee: | Mauri Sergio Alves Palma |
| Support type: | Regular Research Grants |