Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil

Autor(es)

dos Santos, Nathalia Villa ^[1] ; Zilli Vieira, Carolina Leticia ^[2] ; Nascimento Saldiva, Paulo Hilario ^[1] ; Mazzilli, Barbara Paci ^[3] ; Saiki, Mitiko ^[3] ; Saueia, Catia Heloisa ^[3] ; Saldiva De Andre, Carmen Diva ^[4] ; Justo, Lisie Tocci ^[1] ; Nisti, Marcelo Bessa ^[3] ; Koutrakis, Petros ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Lab Expt Air Pollut, Sch Med, Sao Paulo, SP - Brazil

^[2] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 - USA

^[3] IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 JAN 13 2020.
• Citações Web of Science: 0

Resumo

The accumulation of detectable amounts of radon progeny in human tissues may be a risk factor for development and progression of chronic diseases. In this preliminary study, we analyzed the levels of alpha-emitting radon progeny Polonium-210 (Po-210) in the olfactory epithelium, olfactory bulb, frontal lobe, and lung tissues in cadavers from the city of Sao Paulo, SP, Brazil. We also assessed the association between Po-210 levels and exposure parameters for urban air pollution using linear regression models adjusted for age, sex, smoke, time living in Sao Paulo, daily commuting, socioeconomic index, and anthracosis (traffic-related black carbon accumulation in the pleural region and in lymph). Our findings show that the concentration of Po-210 was associated with anthracosis in lungs of non-smokers (coefficient=6.0; standard error=2.9; p=0.04). Individuals with lower socioeconomic status also had significantly higher Po-210 levels in lungs (coefficient=-1.19; standard error=0.58; p=0.042). The olfactory bulb had higher Po-210 levels than either olfactory epithelium (p=0.071), frontal lobe (p<0.001), or lungs (p=0.037). Our findings of the deposition of Po-210 in autopsy tissues suggest that airborne radionuclides may contribute to the development of chronic diseases, including neurodegenerative diseases. (AU)

• Processo FAPESP: 13/21728-2 - Uso de modernas técnicas de autópsia na investigação de doenças humanas (MODAU)
• Beneficiário: Paulo Hilário Nascimento Saldiva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/03461-7 - Comparação da autópsia minimamente invasiva em relação à autópsia convencional para o diagnóstico post-mortem de neoplasias malignas
• Beneficiário: Lisie Tocci Justo Luvizutto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/22793-0 - Doença de Alzheimer no epitélio olfatório: correlação com o meio ambiente
• Beneficiário: Nathalia Villa dos Santos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/23129-7 - Impacto da exposição crônica à poluição atmosférica no envelhecimento do miocárdio
• Beneficiário: Ana Paula Cremasco Takano
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado