| Full text | |
| Author(s): |
dos Santos, Nathalia Villa
[1]
;
Zilli Vieira, Carolina Leticia
[2]
;
Nascimento Saldiva, Paulo Hilario
[1]
;
Mazzilli, Barbara Paci
[3]
;
Saiki, Mitiko
[3]
;
Saueia, Catia Heloisa
[3]
;
Saldiva De Andre, Carmen Diva
[4]
;
Justo, Lisie Tocci
[1]
;
Nisti, Marcelo Bessa
[3]
;
Koutrakis, Petros
[2]
Total Authors: 10
|
| Affiliation: | [1] Univ Sao Paulo, Dept Pathol, Lab Expt Air Pollut, Sch Med, Sao Paulo, SP - Brazil
[2] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 - USA
[3] IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 10, n. 1 JAN 13 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
The accumulation of detectable amounts of radon progeny in human tissues may be a risk factor for development and progression of chronic diseases. In this preliminary study, we analyzed the levels of alpha-emitting radon progeny Polonium-210 (Po-210) in the olfactory epithelium, olfactory bulb, frontal lobe, and lung tissues in cadavers from the city of Sao Paulo, SP, Brazil. We also assessed the association between Po-210 levels and exposure parameters for urban air pollution using linear regression models adjusted for age, sex, smoke, time living in Sao Paulo, daily commuting, socioeconomic index, and anthracosis (traffic-related black carbon accumulation in the pleural region and in lymph). Our findings show that the concentration of Po-210 was associated with anthracosis in lungs of non-smokers (coefficient=6.0; standard error=2.9; p=0.04). Individuals with lower socioeconomic status also had significantly higher Po-210 levels in lungs (coefficient=-1.19; standard error=0.58; p=0.042). The olfactory bulb had higher Po-210 levels than either olfactory epithelium (p=0.071), frontal lobe (p<0.001), or lungs (p=0.037). Our findings of the deposition of Po-210 in autopsy tissues suggest that airborne radionuclides may contribute to the development of chronic diseases, including neurodegenerative diseases. (AU) | |
| FAPESP's process: | 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU) |
| Grantee: | Paulo Hilário Nascimento Saldiva |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/03461-7 - Comparison of minimally invasive autopsy and conventional autopsy for post-mortem malignant neoplasm diagnosis |
| Grantee: | Lisie Tocci Justo Luvizutto |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/22793-0 - Alzheimer's Disease in the olfactory epithelium: correlation with the environment |
| Grantee: | Nathalia Villa dos Santos |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/23129-7 - Impact of long-term exposure to air pollution on myocardium ageing |
| Grantee: | Ana Paula Cremasco Takano |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |