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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil

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Author(s):
dos Santos, Nathalia Villa [1] ; Zilli Vieira, Carolina Leticia [2] ; Nascimento Saldiva, Paulo Hilario [1] ; Mazzilli, Barbara Paci [3] ; Saiki, Mitiko [3] ; Saueia, Catia Heloisa [3] ; Saldiva De Andre, Carmen Diva [4] ; Justo, Lisie Tocci [1] ; Nisti, Marcelo Bessa [3] ; Koutrakis, Petros [2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Pathol, Lab Expt Air Pollut, Sch Med, Sao Paulo, SP - Brazil
[2] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 - USA
[3] IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 JAN 13 2020.
Web of Science Citations: 0
Abstract

The accumulation of detectable amounts of radon progeny in human tissues may be a risk factor for development and progression of chronic diseases. In this preliminary study, we analyzed the levels of alpha-emitting radon progeny Polonium-210 (Po-210) in the olfactory epithelium, olfactory bulb, frontal lobe, and lung tissues in cadavers from the city of Sao Paulo, SP, Brazil. We also assessed the association between Po-210 levels and exposure parameters for urban air pollution using linear regression models adjusted for age, sex, smoke, time living in Sao Paulo, daily commuting, socioeconomic index, and anthracosis (traffic-related black carbon accumulation in the pleural region and in lymph). Our findings show that the concentration of Po-210 was associated with anthracosis in lungs of non-smokers (coefficient=6.0; standard error=2.9; p=0.04). Individuals with lower socioeconomic status also had significantly higher Po-210 levels in lungs (coefficient=-1.19; standard error=0.58; p=0.042). The olfactory bulb had higher Po-210 levels than either olfactory epithelium (p=0.071), frontal lobe (p<0.001), or lungs (p=0.037). Our findings of the deposition of Po-210 in autopsy tissues suggest that airborne radionuclides may contribute to the development of chronic diseases, including neurodegenerative diseases. (AU)

FAPESP's process: 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU)
Grantee:Paulo Hilário Nascimento Saldiva
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/03461-7 - Comparison of minimally invasive autopsy and conventional autopsy for post-mortem malignant neoplasm diagnosis
Grantee:Lisie Tocci Justo Luvizutto
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/22793-0 - Alzheimer's Disease in the olfactory epithelium: correlation with the environment
Grantee:Nathalia Villa dos Santos
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/23129-7 - Impact of long-term exposure to air pollution on myocardium ageing
Grantee:Ana Paula Cremasco Takano
Support type: Scholarships in Brazil - Post-Doctorate