Identification and genomic features of halotolerant extended-spectrum-beta-lactamase (CTX-M)-producing Escherichia coli in urban-impacted coastal waters, Southeast Brazil

Autor(es)

Fernandes, Miriam R. ^[1] ; Sellera, Fabio P. ^[2] ; Moura, Quezia ^[3] ; Esposito, Fernanda ^[1] ; Sabino, Caetano P. ^[1] ; Lincopan, Nilton ^{[4, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo - Brazil

^[3] Fed Univ Grande Dourados, Fac Hlth Sci, Dourados, MS - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Marine Pollution Bulletin; v. 150, JAN 2020.
• Citações Web of Science: 0

Resumo

We report the occurrence and genomic analysis of extended-spectrum beta-lactamase (CTX-M)-producing Escherichia coli in anthropogenically polluted coastal waters of Southeast Brazil. E. coli strains belonging to sequence types (STs) ST10, ST38, ST155 and ST1284 exhibited a wide resistome, with genes conferring resistance to medically relevant antimicrobials and heavy metals, and a halophilic behavior (tolerance to 9-10% NaCl). These findings suggest a heavy contamination in this area by critical priority bacteria adapted to marine environments, which might have negative impacts on human and ocean health. (AU)

• Processo FAPESP: 15/13527-2 - Relação ancestral, pan-resistoma plasmidial de Escherichia coli produtora de b-lactamases de espectro estendido (CTX-M) e métodos de cura plasmidial
• Beneficiário: Miriam Rodriguez Fernandes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/08593-9 - Pan-resistoma de Klebsiella pneumoniae e Escherichia coli produtoras de beta-lactamases (KPC-2, CTX-M-8, CTX-M-15) endêmicas no Brasil
• Beneficiário: Nilton Erbet Lincopan Huenuman
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/03044-7 - Diversidade genética, genes de virulência e resistência antimicrobiana de isolados de Salmonella spp. provenientes de abatedouros de frango
• Beneficiário: Daniel Farias Marinho Do Monte
• Modalidade de apoio: Bolsas no Brasil - Doutorado