Maternal-Fetal Interplay in Zika Virus Infection and Adverse Perinatal Outcomes

Autor(es)

Teixeira, Franciane Mouradian Emidio ^{[1, 2, 3]} ; Pietrobon, Anna Julia ^{[1, 2, 3]} ; Oliveira, Luana de Mendonca ^{[1, 2, 3]} ; Oliveira, Luanda Mara da Silva ^{[1, 3]} ; Sato, Maria Notomi ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Lab Dermatol & Immunodeficiencies, Sch Med, Dept Dermatol, LIM 56, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 11, FEB 14 2020.
• Citações Web of Science: 1

Resumo

During pregnancy, the organization of complex tolerance mechanisms occurs to assure non-rejection of the semiallogeneic fetus. Pregnancy is a period of vulnerability to some viral infections, mainly during the first and second trimesters, that may cause congenital damage to the fetus. Recently, Zika virus (ZIKV) infection has gained great notoriety due to the occurrence of congenital ZIKV syndrome, characterized by fetal microcephaly, which results from the ability of ZIKV to infect placental cells and neural precursors in the fetus. Importantly, in addition to the congenital effects, studies have shown that perinatal ZIKV infection causes a number of disorders, including maculopapular rash, conjunctivitis, and arthralgia. In this paper, we contextualize the immunological aspects involved in the maternal-fetal interface and vulnerability to ZIKV infection, especially the alterations resulting in perinatal outcomes. This highlights the need to develop protective maternal vaccine strategies or interventions that are capable of preventing fetal or even neonatal infection. (AU)

• Processo FAPESP: 17/18199-9 - Efeito da suplementação materna com o ácido retinoico durante a amamentação na resposta imunológica da prole de camundongos
• Beneficiário: Maria Notomi Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/18230-6 - Avaliação da eficácia da vacina de DNA quimérica do Vírus Zika e da proteína de associação à membrana lisossomal em camundongos
• Beneficiário: Franciane Mouradian Emidio Teixeira
• Modalidade de apoio: Bolsas no Brasil - Doutorado