| Texto completo | |
| Autor(es): |
Dos Santos, Marcelo Rodrigues
[1]
;
Peixoto da Fonseca, Guilherme Wesley
[1]
;
Sherveninas, Leticia Pironato
[1]
;
de Souza, Francis Ribeiro
[1]
;
Battaglia Filho, Antonio Carlos
[1]
;
Novaes, Caio Eduardo
[1]
;
Rodrigues Pereira, Rosa Maria
[2]
;
Negrao, Carlos Eduardo
[3, 1]
;
Pereira Barretto, Antonio Carlos
[1]
;
de Nazare Nunes Alves, Maria-Janieire
[1]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Hosp Clin HCFMUSP, Inst Coracao InCor, Fac Med, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Lab Reumatol & Metab Osseo, Fac Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ESC HEART FAILURE; v. 7, n. 3 MAR 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) <40%. Body composition (by using dual x-ray absorptiometry) and peak VO2 (by cardiopulmonary exercise testing) were measured. Sarcopenic obesity was defined according to the Foundation for the National Institutes of Health criteria (FNIH). Blood sample for metabolic and hormonal parameters were measured. Fifteen patients (12.7%) showed sarcopenic obesity (body mass index > 25 kg/m(2) with FNIH index < 0.789). The median A/G ratio was 0.55. A/G ratio > 0.55 was detected in 60 patients. Relative peak VO2 was lower in patients with A/G ratio > 0.55 than in patients with A/G ratio <0.55 (18.7 +/- 5.3 vs. 22.5 +/- 6.1 mL/kg/min, P < 0.001). Logistic regression analysis showed A/G ratio >0.55 to be independently associated with reduced peak VO2 adjusted for age, body mass index, LVEF, presence of sarcopenia, anabolic hormones, and haemoglobin (odds ratio 3.895, 95% confidence interval 1.030-14.730, P = 0.045). Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship. (AU) | |
| Processo FAPESP: | 15/22814-5 - Câncer e coração: novos paradigmas de diagnóstico e tratamento |
| Beneficiário: | Carlos Eduardo Negrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 16/24833-0 - O efeito da neprilisina (LCZ696) sobre a tolerância ao exercício, vasodilatação muscular, força muscular e composição corporal em pacientes com insuficiência cardíaca - NEPRIExTol-HF trial |
| Beneficiário: | Antonio Carlos Pereira-Barretto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/24306-0 - O efeito da Neprilisina (LCZ696) sobre a tolerância ao exercício, vasodilatação muscular, força muscular e composição corporal em pacientes com insuficiência cardíaca |
| Beneficiário: | Marcelo Rodrigues dos Santos |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |