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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure

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Author(s):
Dos Santos, Marcelo Rodrigues [1] ; Peixoto da Fonseca, Guilherme Wesley [1] ; Sherveninas, Leticia Pironato [1] ; de Souza, Francis Ribeiro [1] ; Battaglia Filho, Antonio Carlos [1] ; Novaes, Caio Eduardo [1] ; Rodrigues Pereira, Rosa Maria [2] ; Negrao, Carlos Eduardo [3, 1] ; Pereira Barretto, Antonio Carlos [1] ; de Nazare Nunes Alves, Maria-Janieire [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Hosp Clin HCFMUSP, Inst Coracao InCor, Fac Med, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Lab Reumatol & Metab Osseo, Fac Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ESC HEART FAILURE; v. 7, n. 3 MAR 2020.
Web of Science Citations: 0
Abstract

Aims We studied the association between android (A) to gynoid (G) fat ratio and functional capacity (peak VO2) in male patients with heart failure with reduced ejection fraction (HFrEF). Methods and results We enrolled 118 male patients with HFrEF with left ventricular ejection fraction (LVEF) <40%. Body composition (by using dual x-ray absorptiometry) and peak VO2 (by cardiopulmonary exercise testing) were measured. Sarcopenic obesity was defined according to the Foundation for the National Institutes of Health criteria (FNIH). Blood sample for metabolic and hormonal parameters were measured. Fifteen patients (12.7%) showed sarcopenic obesity (body mass index > 25 kg/m(2) with FNIH index < 0.789). The median A/G ratio was 0.55. A/G ratio > 0.55 was detected in 60 patients. Relative peak VO2 was lower in patients with A/G ratio > 0.55 than in patients with A/G ratio <0.55 (18.7 +/- 5.3 vs. 22.5 +/- 6.1 mL/kg/min, P < 0.001). Logistic regression analysis showed A/G ratio >0.55 to be independently associated with reduced peak VO2 adjusted for age, body mass index, LVEF, presence of sarcopenia, anabolic hormones, and haemoglobin (odds ratio 3.895, 95% confidence interval 1.030-14.730, P = 0.045). Conclusions Body fat distribution, particularly android and gynoid fat composition, together with other cofactors, might have an important adverse role on functional capacity in male patients with HFrEF. Future studies are needed to address possible mechanisms involved in this relationship. (AU)

FAPESP's process: 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment
Grantee:Carlos Eduardo Negrão
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/24833-0 - The effect of neprilysin (LCZ696) on exercise tolerance, muscle vasodilatation, muscle strength and body composition in patients with heart failure - NEPRIExTol-HF trial
Grantee:Antonio Carlos Pereira-Barretto
Support Opportunities: Regular Research Grants
FAPESP's process: 16/24306-0 - The effect of NEPRIlysin (LCZ696) on EXercise TOLerance, muscle vasodilatation, muscle strength and body composition in patients with Heart Failure - NEPRIExTol-HF Trial
Grantee:Marcelo Rodrigues dos Santos
Support Opportunities: Scholarships in Brazil - Post-Doctoral