Clinical aspects, diagnosis and management of Loxosceles spider envenomation: literature and case review

Autor(es)

Lopes, Priscila Hess ^[1] ; Squaiella-Baptistao, Carla Cristina ^[1] ; Marques, Mario Octavio Tha ^[2] ; Tambourgi, Denise V. ^[1]

Afiliação do(s) autor(es)

^[1] Inst Butantan, Lab Imunoquim, Ave Vital Brazil, BR-05503900 Sao Paulo, SP - Brazil

^[2] Univ Fed Santa Catarina, Dept Clin Med, Florianopolis, SC - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ARCHIVES OF TOXICOLOGY; v. 94, n. 5 MAR 2020.
• Citações Web of Science: 1

Resumo

The genus Loxosceles comprises 140 species widely distributed around the world. These spiders are nocturnal, sedentary and remarkably nonaggressive, although they cause accidents in humans with wide degrees of severity, generating signs and symptoms that define the clinical condition known as loxoscelism. Its local signs and symptoms were first reported in 1872, and over the years, a large medical literature has been accumulated; unfortunately, it is not always trustworthy. Assessing the reliability of such information, we reviewed 120 case reports of loxoscelism published in 84 articles over the past 20 years. This search allowed us to gather information on the clinical aspects, diagnosis and treatment of loxoscelism, showing that the severity of these accidents has multiple degrees and that it is influenced by many factors. Thus, coupled with epidemiological and species occurrence information, this study can be a useful tool for the clinical practice of loxoscelism. It may support and provide a multidisciplinary view that should be taken into consideration when establishing the therapeutic approach in cases of Loxosceles envenomation. (AU)

• Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
• Beneficiário: Hugo Aguirre Armelin
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/17053-5 - Estudo da ativação de inflamassomas, em queratinócitos humanos, por ação do veneno da aranha Loxosceles laeta e sua esfingomielinase D
• Beneficiário: Priscila Hess Lopes
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado