Mucin-polysaccharide interactions: A rheological approach to evaluate the effect of pH on the mucoadhesive properties

Autor(es)

de Oliveira Cardoso, Valeria Maria ^[1] ; Daflon Gremiao, Maria Palmira ^[1] ; Ferreira Cury, Beatriz Stringhetti ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, Km 1 Araraquara Jau Rd, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 149, p. 234-245, APR 15 2020.
• Citações Web of Science: 0

Resumo

The design of mucoadhesive drug delivery systems (DDS) based on polysaccharides at nanoscale or microscale is a relevant technological strategy for the mucosal delivery of several drugs. Findings about the potential mucoadhesive ability of these materials and the mechanisms that drive such interactions represents an important advance for the rational modulation of these properties, according to specific uses. The potential mucoadhesive abilities of gellan gum (GG) and retrograded starch (RS) were investigated at pH 1.2 and 6.8, which were considered biorrelevant for the gastrointestinal tract (GIT). The effects of these polysaccharides on the MUC rheology were also addressed. Rheological studies revealed high MUC-GG interactions at both pH values (12 and 6.8), expressing a high mucoadhesive ability, mainly in acidic media. MUC-GG interactions were driven, mainly, by hydrogen bonds. At an acidic pH, significant changes occurred in the MUC arrangements due to the strong MUC-GG interactions, as corroborated by scanning electron microscopy (SEM). The theological behavior of MUC-RS indicated poor interactions between them and MUC arrangements were more preserved as evidenced by SEM. The results of this work indicated that the mixing of GC and RS can be a promising strategy to modulate mucoadhesiveness of DDS, according to specific therapeutic needs. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 17/16324-0 - Sistemas com propriedades mucoadesivas para a liberação de fármacos na mucosa intestinal
• Beneficiário: Maria Palmira Daflon Gremião
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/21412-0 - Sistemas mucoadesivos de gelana/amido retrogradado destinados à liberação colônica do bevacizumabe para o tratamento do câncer colorretal.
• Beneficiário: Valéria Maria de Oliveira Cardoso
• Modalidade de apoio: Bolsas no Brasil - Doutorado