Mucin-polysaccharide interactions: A rheological approach to evaluate the effect of pH on the mucoadhesive properties

Author(s)

de Oliveira Cardoso, Valeria Maria ^[1] ; Daflon Gremiao, Maria Palmira ^[1] ; Ferreira Cury, Beatriz Stringhetti ^[1]

Affiliation

^[1] UNESP Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, Km 1 Araraquara Jau Rd, Araraquara, SP - Brazil

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 149, p. 234-245, APR 15 2020.
• Web of Science Citations: 0

Abstract

The design of mucoadhesive drug delivery systems (DDS) based on polysaccharides at nanoscale or microscale is a relevant technological strategy for the mucosal delivery of several drugs. Findings about the potential mucoadhesive ability of these materials and the mechanisms that drive such interactions represents an important advance for the rational modulation of these properties, according to specific uses. The potential mucoadhesive abilities of gellan gum (GG) and retrograded starch (RS) were investigated at pH 1.2 and 6.8, which were considered biorrelevant for the gastrointestinal tract (GIT). The effects of these polysaccharides on the MUC rheology were also addressed. Rheological studies revealed high MUC-GG interactions at both pH values (12 and 6.8), expressing a high mucoadhesive ability, mainly in acidic media. MUC-GG interactions were driven, mainly, by hydrogen bonds. At an acidic pH, significant changes occurred in the MUC arrangements due to the strong MUC-GG interactions, as corroborated by scanning electron microscopy (SEM). The theological behavior of MUC-RS indicated poor interactions between them and MUC arrangements were more preserved as evidenced by SEM. The results of this work indicated that the mixing of GC and RS can be a promising strategy to modulate mucoadhesiveness of DDS, according to specific therapeutic needs. (C) 2020 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 17/16324-0 - Mucoadhesive delivery systems for the release of drugs on intestinal mucosa
• Grantee: Maria Palmira Daflon Gremião
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/21412-0 - Gellan/retrograded starch mucoadhesives systems intended for the colonic release of bevacizumab to cancer treatment.
• Grantee: Valéria Maria de Oliveira Cardoso
• Support Opportunities: Scholarships in Brazil - Doctorate