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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019

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Jaqueline Goes de Jesus ; Karina Rocha Dutra ; Flavia Cristina da Silva Sales ; Ingra Morales Claro ; Ana Carolina Terzian ; Darlan da Silva Candido ; Sarah C Hill ; Julien Thézé ; Celeste Torres ; Tatiana Lang D’Agostini ; Alvina Clara Felix ; Andreia F Negri Reis ; Luiz Carlos Junior Alcantara ; André L de Abreu ; Júlio HR Croda ; Wanderson K de Oliveira ; Ana Maria Bispo de Filipis ; Maria do Carmo Rodrigues dos Santos Camis ; Camila Malta Romano ; Nick J Loman ; Oliver G Pybus ; Ester Cerdeira Sabino ; Mauricio L Nogueira ; Nuno Rodrigues Faria
Número total de Autores: 24
Tipo de documento: Artigo Científico
Fonte: Memórias do Instituto Oswaldo Cruz; v. 115, p. -, 2020.
Citações Web of Science: 0
Resumo

BACKGROUND Despite efforts to mitigate the impact of dengue virus (DENV) epidemics, the virus remains a public health problem in tropical and subtropical regions around the world. Most DENV cases in the Americas between January and July 2019 were reported in Brazil. São Paulo State in the southeast of Brazil has reported nearly half of all DENV infections in the country. OBJECTIVES To understand the origin and dynamics of the 2019 DENV outbreak. METHODS Here using portable nanopore sequencing we generated20 new DENV genome sequences from viremic patients with suspected dengue infection residing in two of the most-affected municipalities of São Paulo State, Araraquara and São José do Rio Preto. We conducted a comprehensive phylogenetic analysis with 1,630 global DENV strains to better understand the evolutionary history of the DENV lineages that currently circulate in the region. FINDINGS The new outbreak strains were classified as DENV2 genotype III (American/Asian genotype). Our analysis shows that the 2019 outbreak is the result of a novel DENV lineage that was recently introduced to Brazil from the Caribbean region. Dating phylogeographic analysis suggests that DENV2-III BR-4 was introduced to Brazil in or around early 2014, possibly from the Caribbean region. MAIN CONCLUSIONS Our study describes the early detection of a newly introduced and rapidly-expanding DENV2 virus lineage in Brazil. (AU)

Processo FAPESP: 15/14313-6 - Caracterização genética e biológica de isolados de dengue Vírus, Zika vírus e Chikungunya Vírus obtidos de uma coorte prospectiva em São José do Rio Preto, SP
Beneficiário:Karina Rocha Dutra
Linha de fomento: Bolsas no Brasil - Doutorado