| Full text | |
| Author(s): Show less - |
Jaqueline Goes de Jesus
[1]
;
Karina Rocha Dutra
[2]
;
Flavia Cristina da Silva Sales
[3]
;
Ingra Morales Claro
[4]
;
Ana Carolina Terzian
[5]
;
Darlan da Silva Candido
[6]
;
Sarah C Hill
[7]
;
Julien Thézé
[8]
;
Celeste Torres
[9]
;
Tatiana Lang DAgostini
[10]
;
Alvina Clara Felix
[11]
;
Andreia F Negri Reis
[12]
;
Luiz Carlos Junior Alcantara
;
André L de Abreu
[14]
;
Júlio HR Croda
;
Wanderson K de Oliveira
[16]
;
Ana Maria Bispo de Filipis
[17]
;
Maria do Carmo Rodrigues dos Santos Camis
[18]
;
Camila Malta Romano
;
Nick J Loman
[20]
;
Oliver G Pybus
[21]
;
Ester Cerdeira Sabino
[22]
;
Mauricio L Nogueira
[23]
;
Nuno Rodrigues Faria
Total Authors: 24
|
| Affiliation: Show less - | [1] Universidade de São Paulo. Instituto de Medicina Tropical - Brasil
[2] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa em Virologia - Brasil
[3] Universidade de São Paulo. Instituto de Medicina Tropical - Brasil
[4] Universidade de São Paulo. Instituto de Medicina Tropical - Brasil
[5] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa em Virologia - Brasil
[6] University of Oxford. Department of Zoology - Reino Unido
[7] University of Oxford. Department of Zoology - Reino Unido
[8] University of Oxford. Department of Zoology - Reino Unido
[9] Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus - Brasil
[10] Secretaria de Estado da Saúde. Centro de Vigilância Epidemiológica Professor Alexandre Vranjac. Coordenadoria de Controle de Doenças - Brasil
[11] Universidade de São Paulo. Instituto de Medicina Tropical - Brasil
[12] Secretaria Municipal de Saúde - Brasil
[14] Ministério da Saúde. Secretaria de Vigilância em Saúde. Coordenação Geral de Laboratórios de Saúde Pública - Brasil
[16] Ministério da Saúde. Secretaria de Vigilância em Saúde. Coordenação Geral de Laboratórios de Saúde Pública - Brasil
[17] Fundação Oswaldo Cruz-Fiocruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus - Brasil
[18] Secretaria de Estado da Saúde. Centro de Vigilância Epidemiológica Professor Alexandre Vranjac. Coordenadoria de Controle de Doenças - Brasil
[20] University of Birmingham. School of Biosciences. Institute of Microbiology and Infection - Reino Unido
[21] University of Oxford. Department of Zoology - Reino Unido
[22] Universidade de São Paulo. Instituto de Medicina Tropical - Brasil
[23] Faculdade de Medicina de São José do Rio Preto. Laboratório de Pesquisa em Virologia - Brasil
Total Affiliations: 24
|
| Document type: | Journal article |
| Source: | Memórias do Instituto Oswaldo Cruz; v. 115, 2020-05-15. |
| Abstract | |
BACKGROUND Despite efforts to mitigate the impact of dengue virus (DENV) epidemics, the virus remains a public health problem in tropical and subtropical regions around the world. Most DENV cases in the Americas between January and July 2019 were reported in Brazil. São Paulo State in the southeast of Brazil has reported nearly half of all DENV infections in the country. OBJECTIVES To understand the origin and dynamics of the 2019 DENV outbreak. METHODS Here using portable nanopore sequencing we generated20 new DENV genome sequences from viremic patients with suspected dengue infection residing in two of the most-affected municipalities of São Paulo State, Araraquara and São José do Rio Preto. We conducted a comprehensive phylogenetic analysis with 1,630 global DENV strains to better understand the evolutionary history of the DENV lineages that currently circulate in the region. FINDINGS The new outbreak strains were classified as DENV2 genotype III (American/Asian genotype). Our analysis shows that the 2019 outbreak is the result of a novel DENV lineage that was recently introduced to Brazil from the Caribbean region. Dating phylogeographic analysis suggests that DENV2-III BR-4 was introduced to Brazil in or around early 2014, possibly from the Caribbean region. MAIN CONCLUSIONS Our study describes the early detection of a newly introduced and rapidly-expanding DENV2 virus lineage in Brazil. (AU) | |
| FAPESP's process: | 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE) |
| Grantee: | Ester Cerdeira Sabino |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018 |
| Grantee: | Maurício Lacerda Nogueira |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/01735-2 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil |
| Grantee: | Ester Cerdeira Sabino |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/14313-6 - Genetic and biological characterization of Dengue virus, Zika virus and Chikungunya virusisolated in a prospective cohort in SJ Rio Preto, SP |
| Grantee: | Karina Rocha Dutra |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/12295-0 - Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil |
| Grantee: | Ana Carolina Bernardes Terzian |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |