| Grant number: | 15/14313-6 |
| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | March 01, 2018 |
| Effective date (End): | September 30, 2020 |
| Field of knowledge: | Biological Sciences - Microbiology - Biology and Physiology of Microorganisms |
| Principal Investigator: | Maurício Lacerda Nogueira |
| Grantee: | Karina Rocha Dutra |
| Home Institution: | Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil |
| Associated research grant: | 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018, AP.TEM |
Abstract Dengue is one of the most important arbovirus diseases in the world. The Dengue virus belongs to the genus Flavivirus (family Flaviviridae) and has four genetically and antigenically distinct serotypes (DENV-1, DENV-2, DENV-3, DENV-4). The virus is transmitted by Aedes aegypti mosquitoes in tropical and subtropical areas in which climatic conditions favor the maintenance of the vectors. An increase in the genetic variability of the virus has been described, allowing characterize different genotypes and lineages within each serotype that may have significant differences in biological characteristics. To date, there is the deficit of broader studies correlating the epidemiology of the disease, genetic variability and interaction between virus and the host. Therefore, this work intendeds to evaluate the genetic and biological characteristics of Dengue virus samples isolated from patients followed in a prospective cohort study in São Jose do Rio Preto. In addition, in this study is intended to evaluate the incidence and prevalence of distinct serotypes, and, then to analyze phylogenetically the isolated viral strains in the municipality, to correlate genetic variability of viral strains with the multiplication rate, virulence, pathogenicity and to correlate them with the clinical and epidemiological features of patients. | |