Diagnostic of Brazilian and emergent arboviruses in patients and mosquitoes from two distinct regions in Brazil

• Grant number: 15/12295-0
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): March 01, 2016
• Effective date (End): February 29, 2020
• Field of knowledge: Biological Sciences - Microbiology
• Principal researcher: Maurício Lacerda Nogueira
• Grantee: Ana Carolina Bernardes Terzian
• Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Associated research grant: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018, AP.TEM

Abstract

Arboviruses are frequently associated with outbreaks in humans and represent a serious public health problem, with economic and social impacts. Among the Brazilian arboviruses, Mayaro virus, Dengue virus, Yellow Fever virus, Rocio virus and Oropouche virus are responsible for more than 95% of human cases in Brazil. These arboviruses usually present the same clinical symptoms, especially on the acute phase of infection. Today, Brazil is facing a large Dengue outbreak; however, other arboviruses were diagnosed together like Chikungunya and Zika virus. Amazon region is an important area for arboviruses, with the entire basic element to maintain the viral cycle. Equally, São José do Rio Preto, state of São Paulo, is important to the arboviruses surveillance because it is hyper endemic to Dengue and presents circulation of Saint Louis Encephalitis virus and possible other arboviruses for presenting high infestation of the vectors A. aegypti e Culex sp. The aim of this study is to investigate the presence of arboviruses in mosquitoes and patients presenting acute febrile illness in the cities of São José do Rio Preto (SP) and Manaus (AM), two areas with distinct environmental and epidemiological profile but with the presence of Dengue outbreak. The identification of the main Brazilian and emergent arboviruses associated to the vector data could be compared to the results from cohort study performed in the two cities to describe the entrance and circulation of the viral agents in the country. The data will provide tools to help in the surveillance and prevention of outbreaks. (AU)

Scientific publications

(14)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAMASCENO, LUANA; TERZIAN, ANA CAROLINA B.; FULLER, TREVON; ESTOFOLETE, CASSIA F.; ANDRADE, ADRIANA; KROON, ERNA G.; ZIN, ANDREA A.; VASCONCELOS, ZILTON; PEREIRA, JR., JOSE P.; CASTILHO, MARCIA C.; PIAULINO, ISA CRISTINA R.; VASILAKIS, NIKOS; MOREIRA, MARIA E.; NIELSEN-SAINES, KARIN; ESPINOSA, FLOR E. MARTINEZ; NOGUEIRA, MAURICIO L.; BRASIL, PATRICIA. Why Did ZIKV Perinatal Outcomes Differ in Distinct Regions of Brazil? An Exploratory Study of Two Cohorts. Viruses-Basel, v. 13, n. 5 MAY 2021. Web of Science Citations: 0.

COSTA ALECRIM, MARIA DAS GRACAS; RAMOS DE AMORIM, MELANIA MARIA; BARRETO DE ARAUJO, THALIA VELHO; BRASIL, PATRICIA; BRICKLEY, ELIZABETH B.; CASTILHO, MARCIA DA COSTA; COELHO, BERNADETE PEREZ; LEDO ALVES DA CUNHA, ANTONIO JOSE; DUARTE, GERALDO; ESTOFOLETE, CASSIA FERNANDA; GURGEL, RICARDO QUEIROZ; HERRERO-SILVA, JULIANA; HOFER, CRISTINA BARROSO; ALVES LOPES, ALINE SIQUEIRA; TURCHI MARTELLI, CELINA MARIA; DE OLIVEIRA MELO, ADRIANA SUELY; MIRANDA-FILHO, DEMOCRITO DE BARROS; MONTARROYOS, ULISSES RAMOS; MOREIRA, MARIA ELISABETH; MUSSI-PINHATA, MARISA MARCIA; DE OLIVEIRA, CONSUELO SILVA; PASSOS, SAULO DUARTE; PRATA-BARBOSA, ARNALDO; DOS SANTOS, DARCI NEVES; SCHULER-FACCINI, LAVINIA; MOURA DA SILVA, ANTONIO AUGUSTO; DE SIQUEIRA, ISADORA CRISTINA; SOUSA, PATRICIA DA SILVA; TURCHI, MARILIA DALVA; DE ALENCAR XIMENES, RICARDO ARRAES; DE SENE AMANCIO ZARA, ANA LAURA; ZBC-CONSORTIUM. Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy. Viruses-Basel, v. 13, n. 4 APR 2021. Web of Science Citations: 0.

DA ROCHA, LEONARDO CECILIO; ESTOFOLETE, CASSIA FERNANDA; GONCALVES DE AGUIAR MILHIM, BRUNO HENRIQUE; AUGUSTO, MARCOS TAYAR; ZINI, NATHALIA; DUTRA DA SILVA, GISLAINE CELESTINO; FERRAZ-JUNIOR, HELIO CORREA; SABADOTO BRIENZE, VANIA MARIA; LISO, ELISABETE; CUNHA, MARIANA SEQUETIN; SABINO, ESTER CERDEIRA; DA COSTA, ANTONIO CHARLYS; NOGUEIRA, MAURICIO LACERDA; LUCHS, ADRIANA; BERNARDES TERZIAN, ANA CAROLINA. Enteric viruses circulating in undiagnosed central nervous system infections at tertiary hospital in Sao Jose do Rio Preto, Sao Paulo, Brazil. Journal of Medical Virology, v. 93, n. 6 JUL 2020. Web of Science Citations: 2.

JAQUELINE GOES DE JESUS; KARINA ROCHA DUTRA; FLAVIA CRISTINA DA SILVA SALES; INGRA MORALES CLARO; ANA CAROLINA TERZIAN; DARLAN DA SILVA CANDIDO; SARAH C HILL; JULIEN THÉZÉ; CELESTE TORRES; TATIANA LANG D’AGOSTINI; ALVINA CLARA FELIX; ANDREIA F NEGRI REIS; LUIZ CARLOS JUNIOR ALCANTARA; ANDRÉ L DE ABREU; JÚLIO HR CRODA; WANDERSON K DE OLIVEIRA; ANA MARIA BISPO DE FILIPIS; MARIA DO CARMO RODRIGUES DOS SANTOS CAMIS; CAMILA MALTA ROMANO; NICK J LOMAN; OLIVER G PYBUS; ESTER CERDEIRA SABINO; MAURICIO L NOGUEIRA; NUNO RODRIGUES FARIA. Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019. Memórias do Instituto Oswaldo Cruz, v. 115, p. -, 2020. Web of Science Citations: 0.

CHIARAVALLOTI-NETO, FRANCISCO; DA SILVA, RAFAEL ALVES; ZINI, NATHALIA; DUTRA DA SILVA, GISLAINE CELESTINO; DA SILVA, NATAL SANTOS; PEREIRA PARRA, MAISA CARLA; DIBO, MARGARETH REGINA; ESTOFOLETE, CASSIA FERNANDA; FAVARO, ELIANE APARECIDA; DUTRA, KARINA ROCHA; OLIVEIRA MOTA, MANLIO TASSO; GUIMARAES, GEORGIA FREITAS; BERNARDES TERZIAN, ANA CAROLINA; BLANGIARDO, MARTA; NOGUEIRA, MAURICIO LACERDA. Seroprevalence for dengue virus in a hyperendemic area and associated socioeconomic and demographic factors using a cross-sectional design and a geostatistical approach, state of SAo Paulo, Brazil. BMC INFECTIOUS DISEASES, v. 19, MAY 20 2019. Web of Science Citations: 0.

ESTOFOLETE, CASSIA F.; TERZIAN, ANA C. B.; COLOMBO, TATIANA E.; GUIMARAES, GEORGIA DE FREITAS; FERRAZ JUNIOR, HELIO C.; DA SILVA, RAFAEL A.; GREQUE, GILMAR V.; NOGUEIRA, MAURICIO L. Co-infection between Zika and different Dengue serotypes during DENV outbreak in Brazil. JOURNAL OF INFECTION AND PUBLIC HEALTH, v. 12, n. 2, p. 178-181, MAR-APR 2019. Web of Science Citations: 4.

TERZIAN, ANA CAROLINA B.; ZINI, NATHALIA; SACCHETTO, LIVIA; ROCHA, REBECA FROES; PEREIRA PARRA, MAISA CARLA; DEL SARTO, JULIANA LEMOS; FIALHO DIAS, ANA CAROLINA; COUTINHO, FELIPE; RAYRA, JESSICA; DA SILVA, RAFAEL ALVES; COSTA, VIVIAN VASCONCELOS; COUTO DE AZEVEDO FERNANDES, NATALIA COELHO; RESSIO, RODRIGO; DIAZ-DELGADO, JOSUE; GUERRA, JULIANA; CUNHA, MARIANA S.; CATAO-DIAS, JOSE LUIZ; BITTAR, CINTIA; NEGRI REIS, ANDREIA FRANCESLI; PENHA DOS SANTOS, IZALCO NUREMBERG; MARASCALCHI FERREIRA, ANDREIA CRISTINA; ARAO ANTONIO CRUZ, LILIAN ELISA; RAHAL, PAULA; ULLMANN, LEILA; MALOSSI, CAMILA; DE ARAUJO, JR., JOAO PESSOA; WIDEN, STEVEN; DE REZENDE, IZABELA MAURICIO; MELLO, ERICA; PACCA, CAROLINA COLOMBELLI; KROON, ERNA GEESSIEN; TRINDADE, GILIANE; DRUMOND, BETANIA; CHIARAVALLOTI-NETO, FRANCISCO; VASILAKIS, NIKOS; TEIXEIRA, MAURO M.; NOGUEIRA, MAURICIO LACERDA. Evidence of natural Zika virus infection in neotropical non-human primates in Brazil. SCIENTIFIC REPORTS, v. 8, OCT 30 2018. Web of Science Citations: 14.

NOGUEIRA, M. L.; NERY JUNIOR, N. R. R.; ESTOFOLETE, C. F.; BERNARDES TERZIAN, A. C.; GUIMARAES, G. F.; ZINI, N.; ALVES DA SILVA, R.; DUTRA SILVA, G. C.; JUNQUEIRA FRANCO, L. C.; RAHAL, P.; BITTAR, C.; CARNEIRO, B.; VASCONCELOS, P. F. C.; FREITAS HENRIQUES, D.; BARBOSA, D. M. U.; LOPES ROMBOLA, P.; DE GRANDE, L.; NEGRI REIS, A. F.; PALOMARES, S. A.; WAKAI CATELAN, M.; CRUZ, L. E. A. A.; NECCHI, S. H.; MENDONCA, R. C. V.; PENHA DOS SANTOS, I. N.; ALAVARSE CARON, S. B.; COSTA, F.; BOZZA, F. A.; SOARES DE SOUZA, A.; BRANDAO DE MATTOS, C. C.; DE MATTOS, L. C.; VASILAKIS, N.; OLIANI, A. H.; VAZ OLIANI, D. C. M.; KO, A. I. Adverse birth outcomes associated with Zika virus exposure during pregnancy in Sao Jose do Rio Preto, Brazil. Clinical Microbiology and Infection, v. 24, n. 6, p. 646-652, JUN 2018. Web of Science Citations: 13.

COLOMBO, TATIANA ELIAS; ESTOFOLETE, CASSIA FERNANDA; NEGRI REIS, ANDREIA FRANCESLI; DA SILVA, NATAL SANTOS; AGUIAR, MORGANA LIMA; SOTELLO CABRERA, ELIANA MARCIA; PENHA DOS SANTOS, IZALCO NUREMBERG; COSTA, FABIANA RODRIGUES; ARAO ANTONIO CRUZ, LILIAN ELISA; ROMBOLA, PATRICIA LOPES; BERNARDES TERZIAN, ANA CAROLINA; NOGUEIRA, MAURICIO LACERDA. Clinical, laboratory and virological data from suspected ZIKV patients in an endemic arbovirus area. Journal of Clinical Virology, v. 96, p. 20-25, NOV 2017. Web of Science Citations: 12.

TERZIAN, ANA CAROLINA B.; ESTOFOLETE, CASSIA FERNANDA; DA SILVA, RAFAEL ALVES; MOS VAZ-OLIANI, DENISE CRISTINA; OLIANI, ANTONIO HELIO; BRANDAO DE MATTOS, CINARA CASSIA; DE MATTOS, LUIZ CARLOS; RAHAL, PAULA; NOGUEIRA, MAURICIO L. Long-Term Viruria in Zika Virus-Infected Pregnant Women, Brazil, 2016. Emerging Infectious Diseases, v. 23, n. 11, p. 1891-1893, NOV 2017. Web of Science Citations: 6.

BERNARDES TERZIAN, ANA CAROLINA; SCHANOSKI, ALESSANDRA SOARES; DE OLIVEIRA MOTA, MINH' TASSO; DA SILVA, RAFAEL ALVES; ESTOFOLETE, CASSIA FERNANDA; COLOMBO, TATIANA ELIAS; RAHAL, PAULA; HANLEY, KATHRYN A.; VASILAKIS, NIKOS; KALIL, JORGE; NOGUEIRAL, MAURICIO LACERDA. Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients. Clinical Infectious Diseases, v. 65, n. 8, p. 1260-1265, OCT 15 2017. Web of Science Citations: 41.

REN, PING; ORTIZ, DANIEL A.; TERZIAN, ANA C. B.; COLOMBO, TATIANA E.; NOGUEIRA, MAURICIO L.; VASILAKIS, NIKOS; LOEFFELHOLZ, MICHAEL J. Evaluation of Aptima Zika Virus Assay. Journal of Clinical Microbiology, v. 55, n. 7, p. 2198-2203, JUL 2017. Web of Science Citations: 10.

DE SOUZA, ANTONIO SOARES; DIAS, CRISTIANE MORAES; BRAOJOS BRAGA, FERNANDA DEL CAMPO; BERNARDES TERZIAN, ANA CAROLINA; ESTOFOLETE, CASSIA FERNANDA; OLIANI, ANTONIO HELIO; OLIVEIRA, GUSTAVO HENRIQUE; BRANDAO DE MATTOS, CINARA CASSIA; DE MATTOS, LUIZ CARLOS; NOGUEIRA, MAURICIO LACERDA; MOS VAZ-OLIANI, DENISE CRISTINA. Fetal Infection by Zika Virus in the Third Trimester: Report of 2 Cases. Clinical Infectious Diseases, v. 63, n. 12, p. 1622-1625, DEC 15 2016. Web of Science Citations: 32.

ESTOFOLETE, CASSIA FERNANDA; BERNARDES TERZIAN, ANA CAROLINA; PARREIRA, RICARDO; ESTEVES, AIDA; HARDMAN, LUCAS; GREQUE, GILMAR VALDIR; RAHAL, PAULA; NOGUEIRA, MAURICIO LACERDA. Clinical and laboratory profile of Zika virus infection in dengue suspected patients: A case series. Journal of Clinical Virology, v. 81, p. 25-30, AUG 2016. Web of Science Citations: 22.