Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allylnaphthol/phenol derivatives and their anti-Alzheimer activity

Autor(es)

Scheide, Marcos R. ^[1] ; Schneider, Alex R. ^[1] ; Jardim, Guilherme A. M. ^[1] ; Martins, Guilherme M. ^[1] ; Durigon, Daniele C. ^[1] ; Saba, Sumbal ^[2] ; Rafique, Jamal ^[3] ; Braga, Antonio L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Santa Catarina UFSC, Dept Quim, BR-88040900 Florianopolis, SC - Brazil

^[2] Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas CCNH, BR-09210580 Santo Andre, SP - Brazil

^[3] Univ Fed Mato Grosso do Sul UFMS, Inst Quim, BR-79074460 Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORGANIC & BIOMOLECULAR CHEMISTRY; v. 18, n. 26, p. 4916-4921, JUL 14 2020.
• Citações Web of Science: 3

Resumo

Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives. This reaction proceeds with 0.2 equiv. of (Bu4NClO4)-Bu-n as an electrolyte and Pt working electrodes in an undivided cell, resulting in the selenyl-dihydrofurans in good to excellent yields. Furthermore, several of the synthesized products presented a high percentage of acetylcholinesterase (AChE) inhibition, highlighting their potential anti-Alzheimer activity. (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia