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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allylnaphthol/phenol derivatives and their anti-Alzheimer activity

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Author(s):
Scheide, Marcos R. [1] ; Schneider, Alex R. [1] ; Jardim, Guilherme A. M. [1] ; Martins, Guilherme M. [1] ; Durigon, Daniele C. [1] ; Saba, Sumbal [2] ; Rafique, Jamal [3] ; Braga, Antonio L. [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Santa Catarina UFSC, Dept Quim, BR-88040900 Florianopolis, SC - Brazil
[2] Univ Fed ABC UFABC, Ctr Ciencias Nat & Humanas CCNH, BR-09210580 Santo Andre, SP - Brazil
[3] Univ Fed Mato Grosso do Sul UFMS, Inst Quim, BR-79074460 Campo Grande, MS - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ORGANIC & BIOMOLECULAR CHEMISTRY; v. 18, n. 26, p. 4916-4921, JUL 14 2020.
Web of Science Citations: 3
Abstract

Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives. This reaction proceeds with 0.2 equiv. of (Bu4NClO4)-Bu-n as an electrolyte and Pt working electrodes in an undivided cell, resulting in the selenyl-dihydrofurans in good to excellent yields. Furthermore, several of the synthesized products presented a high percentage of acetylcholinesterase (AChE) inhibition, highlighting their potential anti-Alzheimer activity. (AU)

FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support Opportunities: Research Grants - Research Centers in Engineering Program