Prebiotic, antioxidant and anti-inflammatory properties of edible Amazon fruits

Autor(es)

Curimbaba, T. F. S. ^[1] ; Almeida-Junior, L. D. ^[1] ; Chagas, A. S. ^[1] ; Quaglio, A. E. V. ^[1] ; Herculano, A. M. ^[2] ; Stasi, L. C. Di ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Lab Phytomed Pharmacol & Biotechnol PhytoPharmaTe, Dept Pharmacol, Inst Biosci, UNESP, BR-18618689 Botucatu, SP - Brazil

^[2] Fed Univ Para, Inst Biol Sci, Lab Expt Neuropharmacol, BR-66075110 Belem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FOOD BIOSCIENCE; v. 36, AUG 2020.
• Citações Web of Science: 0

Resumo

Dietary products with prebiotic and antioxidant properties may be used to protect against chronic diseases, including inflammatory bowel diseases. Assai berry, burity palm and cupuassu from the Amazon are functional foods because of their high level of dietary fiber and polyphenols, which have an important role in the prevention of inflammatory processes. Their activity as a dietary supplement was measured using fruit pulp flours in a trinitrobenzenesulphonic acid model of intestinal inflammation. The intestinal anti-inflammatory effects were evaluated using clinical parameters and biochemical analysis of pro-inflammatory cytokines (IL-6, IL-1 beta and TNF-alpha), whereas antioxidant activity was studied using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, mieloperoxidase (MPO) and alkaline phosphatase (ALP) activities, glutathione (GSH) level and phenolic content. The effects of dietary supplementation on the mucin release and short-chain fatty acid (SCFA) production were studied. Assai berry and burity palm reduced MPO and ALP activities, counteracted GSH and propionate reductions induced by the inflammatory process as well as decreased IL-6, IL-1 beta and TNF-alpha levels and increased mucin production. Cupuassu reduced MPO and ALP activities, IL-6 and IL-1 beta levels and increased colonic mucin, without effects on the SCFA production and TNF-alpha colonic level. In vitro studies showed the antioxidant properties, which were associated with the presence of polyphenol compounds and scavenging activity using the DPPH assay. The results indicated the possible benefits of using assai berry and burity palm fruits as dietary antioxidant, prebiotic, immune modulators and anti-inflammatory complementary products to treat intestinal inflammation. (AU)

• Processo FAPESP: 15/15267-8 - Doença inflamatória intestinal (DII): novas abordagens de diagnóstico e modulação da microbiota intestinal em pacientes com retocolite ulcerativa
• Beneficiário: Luiz Claudio Di Stasi
• Modalidade de apoio: Auxílio à Pesquisa - Temático