Candida-Associated Denture Stomatitis and Murine Models: What Is the Importance and Scientific Evidence?

Autor(es)

Campos Sugio, Carolina Yoshi ^[1] ; Maia Neves Garcia, Amanda Aparecida ^[1] ; Albach, Thais ^[2] ; Moraes, Gustavo Simao ^[2] ; Bonfante, Estevam Augusto ^[1] ; Urban, Vanessa Migliorini ^[2] ; Neppelenbroek, Karin Hermana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodont, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil

^[2] Univ Estadual Ponta Grossa, Dept Dent, Ave Gen Carlos Cavalcanti 4748, BR-84030900 Ponta Grossa, PR - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF FUNGI; v. 6, n. 2 JUN 2020.
• Citações Web of Science: 0

Resumo

Considering the high prevalence and recurrence ofCandida-associated denture stomatitis (CADS), in vivo studies in animal models are necessary before those in humans to evaluate new therapeutic strategies. This study aimed to review the literature on murine models of CADS induction using acrylic intraoral devices simulating dentures. Rats are recommended as experimental animals in these models as well as the adoption of a pasty diet. For maintenance in the proper position during the experiments, intraoral appliances must be obtained by individual impressions, using and retained exclusively by cementation on the molars. The region of interest for histopathological analysis was standardized as that corresponding to the area between the first molars. However, there is no consensus among the studies on the CADS induction rat models in relation to theCandida albicansinoculation and need for immunosuppression and/or administration of antibacterial drugs of animals. The greatest difficulty of the available models refers to maintaining the course of the lesion for a sufficient period to evaluate the effectiveness of the proposed treatment, considering the rapid and efficient murine immune response to candidal colonization. Therefore, future studies are necessary for the development of a robust and reproducible CADS model. (AU)

• Processo FAPESP: 17/07314-1 - Avaliação clínica da adição de antifúngicos a reembasador resiliente temporário no tratamento da estomatite protética
• Beneficiário: Karin Hermana Neppelenbroek
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/22996-1 - Resposta tecidual em modelo animal de condicionador de tecido contendo complexo de inclusão antifúngico: ²-ciclodextrina para tratamento de estomatite protética
• Beneficiário: Carolina Yoshi Campos Sugio
• Modalidade de apoio: Bolsas no Brasil - Mestrado