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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of dentin biomodification delivered by experimental acidic and neutral primers on resin adhesion

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Autor(es):
Trevelin, Livia Tosi [1, 2] ; Alania, Yvette [1] ; Mathew, Mathew [1] ; Phansalkar, Rasika [3, 4] ; Chen, Shao-Nong [3, 4] ; Pauli, Guido F. [3, 4] ; Bedran-Russo, Ana K. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Illinois, Coll Dent, Dept Restorat Dent, Chicago, IL - USA
[2] Univ Sao Caetano Do Sul, Coll Dent, Dept Operat Dent, USCS, Sao Caetano do Sul - Brazil
[3] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 - USA
[4] Univ Illinois, Coll Pharm, Dept Pharmaceut Sci, Chicago, IL - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Journal of Dentistry; v. 99, AUG 2020.
Citações Web of Science: 0
Resumo

Objectives: Proanthocyanidins (PACs) are biocompounds mimicking native collagen cross-links. The effective and practical delivery of any biocompound is pivotal for clinical usage. The aim was to investigate the dentin biomodification and effective formation of dentin-resin biointerfaces of two highly bioactive PAC-rich extracts, Vitis vinifera (Vv) and Camellia sinensis (Cs), delivered using neutral (NP) or acidic (AP) rinse-out primer approaches. Methods: The depth of dentin demineralization (optical profilometry), dentin biomodification (apparent modulus of elasticity, collagen auto-fluorescence) and properties of dentin-resin interfaces (microtensile bond strength - mu TBS, and micro-permeability) were investigated. NP consisted of either 15% Vv or Cs applied for 60 s after surface etching; while AP contained 15% Vv or Cs in either 35% glycolic acid or tartaric acid applied for 30 s or 60 s. Data were analyzed using ANOVA and post-hoc tests (alpha = 0.05). Results: The depth of demineralization was statistically higher when applied for 60 s, regardless of rinse-out primer approach (p < 0.001). Compared to the AP strategy, NP exhibited statistically higher apparent modulus of elasticity, regardless of PAC extract (p < 0.001). Highest mu TBS were obtained for NPVv, which were statistically similar to AP(GAVv), when applied for 60 s (p < 0.001); both resulted in a dramatic decrease of the interfacial permeability. NPCs, group showed the lowest mu TBS (p < 0.001). Conclusions: A combination of high bond strength and low micro-permeability can be accomplished using glycolic acid with the mid- and high-PAC oligomer enriched extract (Vv). Cs extract containing mostly catechins and dimeric PACs, was found unsuitable for resin-dentin adhesion despite exhibiting high initial dentin biomodification. Clinical significance: This study provides a new conceptual delivery of PAC-mediated dentin biomodification and conservative dentin surface etching using rinse-out primers. The strategy requires a specific combination of PAC source, alpha-hydroxy acid, and application time. (AU)

Processo FAPESP: 15/12651-1 - Influência da largura temporal de pulso do laser de Er:YAG na morfologia dentinária, na formação da camada híbrida e na resistência adesiva
Beneficiário:Lívia Tosi Trevelin
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/18118-6 - Novas estratégias para prevenir a degradação da interface adesiva
Beneficiário:Lívia Tosi Trevelin
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado