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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A New Insight into the Surgical Treatment of Primary Macronodular Adrenal Hyperplasia

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Autor(es):
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Tanno, Fabio Yoshiaki [1] ; Srougi, Victor [1] ; Almeida, Madson Q. [2] ; Yamauchi, Fernando Ide [3] ; Almeida Coelho, Fernando Morbeck [3] ; Nishi, Mirian Yumie [1] ; Nogueira Zerbini, Maria Claudia [4] ; Correa Soares, Iracy Silvia [5] ; Albergaria Pereira, Maria Adelaide [2] ; Silva Charchar, Helaine Laiz [2] ; Ferreira Lacombe, Amanda Meneses [2] ; Brondani, Vania Balderrama [2] ; Srougi, Miguel [1] ; Nahas, Willian Carlos [1] ; Mendonca, Berenice B. [2] ; Chambo, Jose Luis [1] ; Barisson Villares Fragoso, Maria Candida [2]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Hosp Clin, Div Urol, Fac Med, Av Doutor Eneas Carvalho Aguiar 255, 7 Andar, BR-05403900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Hosp Clin, Serv Endocrinol & Metabol, Unidade Suprarrenal, Lab Hormonios & Genetv Mol LI, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Radiol INRAD, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Div Anat Patol, Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Hosp Clin, Serv Anestesiol, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF THE ENDOCRINE SOCIETY; v. 4, n. 8 AUG 2020.
Citações Web of Science: 0
Resumo

Purpose: This prospective study presents the results of a new approach in the treatment of primary macronodular adrenal hyperplasia (PMAII), with simultaneous total adrenalectomy of the larger adrenal gland and partial adrenalectomy of the contralateral adrenal gland (adrenal-sparing surgery). Materials and Methods: We performed a prospective study including 17 patients with PMAH treated surgically with adrenal-sparing surgery in a tertiary referral hospital, with a median follow-up of 41 months. Clinical, hormonal, and genetic parameters were evaluated before surgery and during follow-up. All patients had at least 1 radiological examination before and after the procedure. Results: Among the 17 patients, all but 1 patient had complete hypercortisolism control, and 12 recovered normal adrenal function after surgery. Significant improvement in clinical parameters was observed: weight loss (P = .004); reduction of both systolic (P = .001) and diastolic (P = .001) blood pressure; and reduction in the number of antihypertensive drugs (P < .001). Intra-, peri-, and postoperative complications were not observed. Conclusion: Adrenal-sparing surgery is a safe and feasible procedure to treat patients with PMAH, providing a substantial chance of hypercortisolism control without the disadvantages of lifetime corticosteroid replacement. (C) Endocrine Society 2020. (AU)

Processo FAPESP: 15/50192-9 - Avanços na compreensão da fisiopatologia da hiperplasia macronodular adrenocortical primária - PMAH (GP-PMAH)
Beneficiário:Maria Candida Barisson Villares Fragoso
Linha de fomento: Auxílio à Pesquisa - Temático