Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

Autor(es)

Andreotti, Diana Zukas ^[1] ; Silva, Josiane do Nascimento ^[1] ; Matumoto, Amanda Midori ^[1] ; Orellana, Ana Maria ^[2] ; de Mello, Paloma Segura ^[2] ; Kawamoto, Elisa Mitiko ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Lab Mol & Funct Neurobiol, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Lab Mol Neuropharmacol, Dept Pharmacol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: FRONTIERS IN NUTRITION; v. 7, JUL 28 2020.
• Citações Web of Science: 0

Resumo

The aging process is characterized by a series of molecular and cellular changes over the years that could culminate in the deterioration of physiological parameters important to keeping an organism alive and healthy. Physical exercise, defined as planned, structured and repetitive physical activity, has been an important force to alter physiology and brain development during the process of human beings' evolution. Among several aspects of aging, the aim of this review is to discuss the balance between two vital cellular processes such as autophagy and apoptosis, based on the fact that physical exercise as a non-pharmacological strategy seems to rescue the imbalance between autophagy and apoptosis during aging. Therefore, the effects of different types or modalities of physical exercise in humans and animals, and the benefits of each of them on aging, will be discussed as a possible preventive strategy against neuronal death. (AU)

• Processo FAPESP: 16/22996-9 - Avaliação dos efeitos do exercício físico na cognição de animais com deleção da PTEN em neurônios
• Beneficiário: Elisa Mitiko Kawamoto Iwashe
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/07427-8 - Envelhecimento e neuroproteção: ações da proteína Klotho no metabolismo energético, sinalização da Na,K-ATPase e respostas adaptativas no sistema nervoso central
• Beneficiário: Cristoforo Scavone
• Modalidade de apoio: Auxílio à Pesquisa - Temático