Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies

Full text
Author(s):
Andreotti, Diana Zukas [1] ; Silva, Josiane do Nascimento [1] ; Matumoto, Amanda Midori [1] ; Orellana, Ana Maria [2] ; de Mello, Paloma Segura [2] ; Kawamoto, Elisa Mitiko [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Lab Mol & Funct Neurobiol, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Lab Mol Neuropharmacol, Dept Pharmacol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN NUTRITION; v. 7, JUL 28 2020.
Web of Science Citations: 0
Abstract

The aging process is characterized by a series of molecular and cellular changes over the years that could culminate in the deterioration of physiological parameters important to keeping an organism alive and healthy. Physical exercise, defined as planned, structured and repetitive physical activity, has been an important force to alter physiology and brain development during the process of human beings' evolution. Among several aspects of aging, the aim of this review is to discuss the balance between two vital cellular processes such as autophagy and apoptosis, based on the fact that physical exercise as a non-pharmacological strategy seems to rescue the imbalance between autophagy and apoptosis during aging. Therefore, the effects of different types or modalities of physical exercise in humans and animals, and the benefits of each of them on aging, will be discussed as a possible preventive strategy against neuronal death. (AU)

FAPESP's process: 16/22996-9 - Evaluation of physical exercise effects on cognition of neuronal-PTEN deleted animals
Grantee:Elisa Mitiko Kawamoto Iwashe
Support Opportunities: Regular Research Grants
FAPESP's process: 16/07427-8 - Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system
Grantee:Cristoforo Scavone
Support Opportunities: Research Projects - Thematic Grants