Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia

Autor(es)

VITOR N. MORAES ^[1] ; ANDRÉ L. QUEIROZ ^[2] ; DANIEL MARTONE ^[3] ; JHENNYFER A.L. RODRIGUES ^[4] ; MATHEUS M. GOMES ^[5] ; WILSON SALGADO JÚNIOR ^[6] ; CARLOS ROBERTO BUENO JR

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil

^[2] Weill Cornell Medicine - Estados Unidos

^[3] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil

^[4] Universidade de São Paulo. Escola de Educação Física e Esporte de Ribeirão Preto - Brasil

^[5] Universidade de São Paulo. Escola de Educação Física e Esporte de Ribeirão Preto - Brasil

^[6] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Anais da Academia Brasileira de Ciências; v. 92, n. 4 2020-11-20.

Resumo

Abstract The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact this disease. The aim of this study was to verify the relationship between the FTO gene and the hsa-miR-150-5p expression with overweight/obesity, lipid profile, and fast blood glucose. Men and women (18 years older or above), with body mass index ≥ 18.5 kg/m2, were enrolled in the present study and the FTO gene and hsa-miR-150-5p expression, biochemical parameters of blood and anthropometric measurements were analyzed. The results highlight that the FTO gene expression is associated to obesity (p 0.029), LDL-C (p 0.02) and fasting blood glucose (p 0.02), but not with triglycerides (p 0.69), total cholesterol (p 0.21), and HDL-C (p 0.24). The hsa-miR-150-5p is not associated to obesity (p 0.84), triglycerides (p 0.57), total cholesterol (p 0.51), HDL-C (p 0.75), LDL-C (p 0.32), and fasting blood glucose (p 0.42). The FTO gene expression is related to obesity, LDL-C and blood fasting glucose, representing a good molecular marker for obesity. (AU)

• Processo FAPESP: 13/21159-8 - Influência de polimorfismos genéticos nos efeitos de dois tipos de treinamento físico aeróbio intervalado de alta intensidade em indivíduos com síndrome metabólica
• Beneficiário: Carlos Roberto Bueno Júnior
• Modalidade de apoio: Auxílio à Pesquisa - Regular