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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia

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Author(s):
VITOR N. MORAES [1] ; ANDRÉ L. QUEIROZ [2] ; DANIEL MARTONE [3] ; JHENNYFER A.L. RODRIGUES [4] ; MATHEUS M. GOMES [5] ; WILSON SALGADO JÚNIOR [6] ; CARLOS ROBERTO BUENO JR
Total Authors: 7
Affiliation:
[1] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
[2] Weill Cornell Medicine - Estados Unidos
[3] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
[4] Universidade de São Paulo. Escola de Educação Física e Esporte de Ribeirão Preto - Brasil
[5] Universidade de São Paulo. Escola de Educação Física e Esporte de Ribeirão Preto - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Anais da Academia Brasileira de Ciências; v. 92, n. 4 2020-11-20.
Abstract

Abstract The overweight population is growing in the world, and the search for obesity-associated mechanisms is important for a better understanding of this disease. Few studies with the FTO gene and miRs show how they associate to obesity and how they can impact this disease. The aim of this study was to verify the relationship between the FTO gene and the hsa-miR-150-5p expression with overweight/obesity, lipid profile, and fast blood glucose. Men and women (18 years older or above), with body mass index ≥ 18.5 kg/m2, were enrolled in the present study and the FTO gene and hsa-miR-150-5p expression, biochemical parameters of blood and anthropometric measurements were analyzed. The results highlight that the FTO gene expression is associated to obesity (p 0.029), LDL-C (p 0.02) and fasting blood glucose (p 0.02), but not with triglycerides (p 0.69), total cholesterol (p 0.21), and HDL-C (p 0.24). The hsa-miR-150-5p is not associated to obesity (p 0.84), triglycerides (p 0.57), total cholesterol (p 0.51), HDL-C (p 0.75), LDL-C (p 0.32), and fasting blood glucose (p 0.42). The FTO gene expression is related to obesity, LDL-C and blood fasting glucose, representing a good molecular marker for obesity. (AU)

FAPESP's process: 13/21159-8 - Influence of genetics polymorphisms in effects of two types of high intensity aerobic interval training in patients with metabolic syndrome
Grantee:Carlos Roberto Bueno Júnior
Support Opportunities: Regular Research Grants