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Influence of genetics polymorphisms in effects of two types of high intensity aerobic interval training in patients with metabolic syndrome

Grant number: 13/21159-8
Support type:Regular Research Grants
Duration: June 01, 2014 - May 31, 2016
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Carlos Roberto Bueno Júnior
Grantee:Carlos Roberto Bueno Júnior
Home Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers: Arnt Erik Tjonna ; Patricia Chakur Brum

Abstract

Recent studies have demonstrated that metabolic syndrome (MS) prevalence is over 35% in Brazil and aerobic training (AT) is an important non pharmacological therapy for MS. Although the majority of professionals prescribe 150 min of moderate intensity AT per week, it has been speculated that high intensity interval AT can result in superior benefits. Furthermore, a clear indication of minimum time required for optimized benefits in a single AT session needs to be investigated. Finally, the responsiveness to AT varies among different patients, which can be explained by genetic variations. Therefore, the purposes of this study are: 1) to evaluate in MS patients health parameters related to the disease and maximal oxygen uptake, analyzing the effects of high intensity interval AT (it will be tested two different volumes) versus moderate intensity AT and 2) to screen for polymorphisms in ACE, AGTR1, AKT1 and visfatin genes and evaluate their relationship to exercise responsiveness to the three types of AT. Males and females MS patients (age e 30) will be randomized and stratified (age and sex) in three groups: interval AT three times a week, 4x4min (85% of maximal oxygen uptake); interval AT three times a week, 1x4 min (85% of maximal oxygen uptake); and traditional AT three times a week (55% of maximal oxygen uptake, 47 min per session). Sample size will be estimated based on the variability from a pilot study (n=10 per group). The results of this study will provide important issues to genetic characteristics to be considered in the choice of the more efficient AT for each patient. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TRAPE, ATILA ALEXANDRE; RODRIGUES, JHENNYFER ALINE LIMA; FEREZIN, LETICIA PERTICARRARA; FERRARI, GUSTAVO DUARTE; LIZZI, ELISANGELA APARECIDA DA SILVA; DE MORAES, VITOR NOLASCO; DA SILVA, ROBERTA FERNANDA; ZAGO, ANDERSON SARANZ; BRAZO-SAYAVERA, JAVIER; BUENO JUNIOR, CARLOS ROBERTO. NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women. FRONTIERS IN PHYSIOLOGY, v. 12, MAR 10 2021. Web of Science Citations: 0.
PORTO GONCALVES, THIAGO CORREA; TRAPE, ATILA ALEXANDRE; LIMA RODRIGUES, JHENNYFER ALINE; TAVARES, SIMONE SAKAGUTE; BUENO JUNIOR, CARLOS ROBERTO. Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of beta(2) Adrenergic Receptor Haplotypes. JOURNAL OF AGING AND PHYSICAL ACTIVITY, v. 28, n. 2, p. 242-249, APR 2020. Web of Science Citations: 0.
LIMA RODRIGUES, JHENNYFER ALINE; FERRARI, GUSTAVO DUARTE; TRAPE, ATILA ALEXANDRE; DE MORAES, VITOR NOLASCO; PORTO GONCALVES, THIAGO CORREA; TAVARES, SIMONE SAKAGUTE; TJONNA, ARNT ERIK; DUTRA DE SOUZA, HUGO CELSO; BUENO JUNIOR, CARLOS ROBERTO. beta(2) adrenergic interaction and cardiac autonomic function: effects of aerobic training in overweight/obese individuals. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 120, n. 3, p. 613-624, MAR 2020. Web of Science Citations: 0.
CAMILA DE PAULA MONTEIRO; MARIANA LUCIANO DE ALMEIDA; CARLOS ROBERTO BUENO JÚNIOR. DANCE IN THE TREATMENT OF CHILDHOOD OBESITY: A PROPOSED PROTOCOL. Revista Brasileira de Medicina do Esporte, v. 26, n. 1, p. 43-47, Fev. 2020. Web of Science Citations: 0.
VITOR N. MORAES; ANDRÉ L. QUEIROZ; DANIEL MARTONE; JHENNYFER A.L. RODRIGUES; MATHEUS M. GOMES; WILSON SALGADO JÚNIOR; CARLOS ROBERTO BUENO JR. Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia. Anais da Academia Brasileira de Ciências, v. 92, n. 4, p. -, 2020. Web of Science Citations: 0.
RODRIGUES, J. A. L.; YAMANE, A. C.; GONCALVES, T. C. P.; KALVA-FILHO, C.; PAPOTI, M.; JUNIOR, C. R. B. Fed and fasted states on heart rate variability, hemodynamic heart rate and blood pressure in adults submitted to moderate aerobic exercise. IJC HEART & VASCULATURE, v. 23, JUN 2019. Web of Science Citations: 0.
TRAPE, ATILA ALEXANDRE; DA SILVA LIZZI, ELISANGELA APARECIDA; PORTO GONCALVES, THIAGO CORREA; LIMA RODRIGUES, JHENNYFER ALINE; TAVARES, SIMONE SAKAGUTE; LACCHINI, RICCARDO; PINHEIRO, LUCAS CEZAR; FERREIRA, GRAZIELE CRISTINA; TANUS-SANTOS, JOSE EDUARDO; OVIDIO, PAULA PAYAO; JORDAO, ALCEU AFONSO; JACOMINI, ANDRE MOURAO; ZAGO, ANDERSON SARANZ; BUENO JUNIOR, CARLOS ROBERTO. Effect of Multicomponent Training on Blood Pressure, Nitric Oxide, Redox Status, and Physical Fitness in Older Adult Women: Influence of Endothelial Nitric Oxide Synthase (NOS3) Haplotypes. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.