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Effects of high-intensity interval training on skeletal muscle of Walker 256 tumor-bearing rats

Grant number: 12/25240-1
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): February 20, 2013
Effective date (End): August 19, 2013
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Julio Cesar Batista Ferreira
Grantee:Christiano Robles Rodrigues Alves
Supervisor abroad: Ulrik Wisloff
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Norwegian University of Science and Technology (NTNU), Norway  
Associated to the scholarship:12/02528-0 - Effects of high-intensity physical training on skeletal muscle of Walker 256 tumor-bearing rats, BP.MS


Given the impact of cachexia on survival and the quality and life of cancer patients, strategies that attenuate the muscle atrophy are necessary. Recent evidence suggests that high-intensity interval aerobic training is more effective than moderate-intensity aerobic training to promote functional adaptations in skeletal muscle and exercise performance in healthy subjects in chronic diseases such as heart failure and metabolic syndrome. Unfortunately, the effect of high-intensity interval aerobic training on skeletal muscle in cancer-cachexia models has not yet been evaluated. Thus, in this research project we propose an experimental study to assess and compare the impact of moderate-intensity continuous aerobic training and high-intensity interval training in skeletal muscle of tumor-bearing rats. Forty rats will randomize into four groups, namely: 1) control, 2) with cancer and sedentary, 3) with cancer and submitted to moderate-intensity continuous aerobic training and 4) with cancer and submitted to high-intensity interval aerobic training. The groups with cancer will be inoculate with Walker 256 tumor. After 14 days of tumor inoculation, the animals will be beheaded. This study will be evaluated the following parameters: the tumor mass, body weight, food consumption, tolerance to exercise, maximal aerobic power, the skeletal muscles function, and cross-sectional area, the activity of the proteasome at the chymotrypsin site, the gene and protein expression of E3 ligases (i.e. Atrogin-1 and MuRF1), the tissue concentration of pro-and anti-inflammatory (e. g. TNF-±, IL-6, IL-1² and IL10) and ubiquinized protein expression in skeletal muscles Soleus and EDL. Additionally, we are requiring the BEPE to learn and to perform new analyzes upon this tissue metabolism, such as mitochondrial respiration in permeabilized fibers. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, RODRIGO W. A.; ALVES, CHRISTIANO R. R.; MEDEIROS, ALESSANDRA; ROLIM, NATALE; SILVA, GUSTAVO J. J.; MOREIRA, JOSE B. N.; ALVES, MARCIA N.; WOHLWEND, MARTIN; GEBRIEL, MOHAMMED; HAGEN, LARS; SHARMA, ANIMESH; KOCH, LAUREN G.; BRITTON, STEVEN L.; SLUPPHAUG, GEIR; WISLOFF, ULRIK; BRUM, PATRICIA C. Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. SCIENTIFIC REPORTS, v. 8, DEC 11 2018. Web of Science Citations: 1.
ALVES, CHRISTIANO R. R.; FARIA, DANIELE DE P.; CARNEIRO, CAMILA DE G.; GARCEZ, ALEXANDRE T.; GUTIERREZ, VANESSA P.; DAS NEVES, WILLIAN; DE ALMEIDA, NEY R.; CURY, YARA; CHAMMAS, ROGER; BRUM, PATRICIA C. F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents. Life Sciences, v. 206, p. 29-34, AUG 1 2018. Web of Science Citations: 0.
DE CAMPOS-FERRAZ, PATRICIA LOPES; ANDRADE, ISABEL; DAS NEVES, WILLIAN; HANGAI, ISABELA; RODRIGUES ALVES, CHRISTIANO ROBLES; LANCHA, JR., ANTONIO HERBERT. An overview of amines as nutritional supplements to counteract cancer cachexia. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 5, n. 2, p. 105-110, JUN 2014. Web of Science Citations: 18.

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