| Texto completo | |
| Autor(es): |
Fabri, Joao Henrique Tadini Marilhano
[1, 2]
;
de Sa, Nivea Pereira
[2]
;
Malavazi, Iran
[1]
;
Del Poeta, Maurizio
[3, 2, 4]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Carlos, Dept Genet & Evolucao, Ctr Ciencias Biol & Saude, Sao Carlos, SP - Brazil
[2] SUNY Stony Brook, Dept Microbiol & Immunol, Stony Brook, NY 11794 - USA
[3] SUNY Stony Brook, Sch Med, Div Infect Dis, Stony Brook, NY 11794 - USA
[4] Vet Adm Med Ctr, Northport, NY 11768 - USA
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | PROGRESS IN LIPID RESEARCH; v. 80, NOV 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
All living beings have an optimal temperature for growth and survival. With the advancement of global warming, the search for understanding adaptive processes to climate changes has gained prominence. In this context, all living beings monitor the external temperature and develop adaptive responses to thermal variations. These responses ultimately change the functioning of the cell and affect the most diverse structures and pro-cesses. One of the first structures to detect thermal variations is the plasma membrane, whose constitution allows triggering of intracellular signals that assist in the response to temperature stress. Although studies on this topic have been conducted, the underlying mechanisms of recognizing thermal changes and modifying cellular functioning to adapt to this condition are not fully understood. Recently, many reports have indicated the participation of sphingolipids (SLs), major components of the plasma membrane, in the regulation of the thermal stress response. SLs can structurally reinforce the membrane or/and send signals intracellularly to control numerous cellular processes, such as apoptosis, cytoskeleton polarization, cell cycle arresting and fungal virulence. In this review, we discuss how SLs synthesis changes during both heat and cold stresses, focusing on fungi, plants, animals and human cells. The role of lysophospholipids is also discussed. (AU) | |
| Processo FAPESP: | 17/19694-3 - Identificação do papel das proteínas de choque térmico HsfA e Hsp90 e do regulador SmiA na atividade da via da integridade da parede celular no fungo patogênico oportunista humano Aspergillus fumigatus |
| Beneficiário: | Iran Malavazi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/07870-9 - A influência de proteínas quinases ativadas por mitógenos (MAPK) na expressão de determinantes genéticos importantes para a virulência de Aspergillus fumigatus |
| Beneficiário: | Gustavo Henrique Goldman |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |