| Full text | |
| Author(s): |
Fabri, Joao Henrique Tadini Marilhano
[1, 2]
;
de Sa, Nivea Pereira
[2]
;
Malavazi, Iran
[1]
;
Del Poeta, Maurizio
[3, 2, 4]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Carlos, Dept Genet & Evolucao, Ctr Ciencias Biol & Saude, Sao Carlos, SP - Brazil
[2] SUNY Stony Brook, Dept Microbiol & Immunol, Stony Brook, NY 11794 - USA
[3] SUNY Stony Brook, Sch Med, Div Infect Dis, Stony Brook, NY 11794 - USA
[4] Vet Adm Med Ctr, Northport, NY 11768 - USA
Total Affiliations: 4
|
| Document type: | Review article |
| Source: | PROGRESS IN LIPID RESEARCH; v. 80, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
All living beings have an optimal temperature for growth and survival. With the advancement of global warming, the search for understanding adaptive processes to climate changes has gained prominence. In this context, all living beings monitor the external temperature and develop adaptive responses to thermal variations. These responses ultimately change the functioning of the cell and affect the most diverse structures and pro-cesses. One of the first structures to detect thermal variations is the plasma membrane, whose constitution allows triggering of intracellular signals that assist in the response to temperature stress. Although studies on this topic have been conducted, the underlying mechanisms of recognizing thermal changes and modifying cellular functioning to adapt to this condition are not fully understood. Recently, many reports have indicated the participation of sphingolipids (SLs), major components of the plasma membrane, in the regulation of the thermal stress response. SLs can structurally reinforce the membrane or/and send signals intracellularly to control numerous cellular processes, such as apoptosis, cytoskeleton polarization, cell cycle arresting and fungal virulence. In this review, we discuss how SLs synthesis changes during both heat and cold stresses, focusing on fungi, plants, animals and human cells. The role of lysophospholipids is also discussed. (AU) | |
| FAPESP's process: | 17/19694-3 - The role of heat shock proteins HsfA and Hsp90 and the regulator SmiA at cell wall integrity pathway activity in the opportunistic human pathogen Aspergillus fumigatus |
| Grantee: | Iran Malavazi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/07870-9 - The influence of mitogen activated protein kinases (MAPK) on the expression of genetic determinants important for Aspergillus fumigatus virulence |
| Grantee: | Gustavo Henrique Goldman |
| Support Opportunities: | Research Projects - Thematic Grants |