Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker

Autor(es)

de Souza Teixeira, Alexandre Abilio ^[1] ; Lira, Fabio Santos ^[2] ; Rosa-Neto, Jose Cesar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil

^[2] Univ Estadual Paulista UNESP, Sch Technol & Sci, Dept Phys Educ, Exercise & Immunometab Res Grp, Postgrad Program M, Presidente Prudente, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Life Sciences; v. 261, NOV 15 2020.
• Citações Web of Science: 0

Resumo

Aging is associated with gradual decline in numerous physiological processes, including a reduction in metabolic functions and immunological system. The circadian rhythm plays a vital role in health, and prolonged clock disruptions are associated with chronic diseases. The relationships between clock genes, aging, and immunosenescence are not well understood. Inflammation is an immune response triggered in living organisms in response to the danger associated with pathogens and injury. The term Inflammaging' has been used to describe the chronic low-grade-inflammation that develops with advancing age and predicts susceptibility to age-related pathologies. Equilibrium between pro-and anti-inflammatory cytokines is needed for healthy aging and longevity. Sedentary and poor nutrition style life indices a disruption in circadian rhythm promoting an increase in pro-inflammatory factors or leads for chronic low-grade inflammation. Moreover, signals mediated by pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6, might accentuate of the muscle loss during aging. Circadian clock is important to maintain the physiological functions, as maintenance of immune system. A strategy for imposes rhythmicity in the physiological systems may be adopted of exercise training routine. The lifelong regular practice of physical exercise decelerates the processes of aging, providing better quality and prolongation of life. Thus, in this review, we will focus on how aging affects circadian rhythms and its relationship to inflammatory processes (inflammaging), as well as the role of physical exercise as a regulator of the circadian rhythm, promoting aging with rhythmicity. (AU)

• Processo FAPESP: 15/16777-0 - Exercício físico como um sincronizador dos ritmos circadianos no câncer
• Beneficiário: Alexandre Abilio de Souza Teixeira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/01409-8 - Caracterização do efeito antiinflamatório da suplementação com ácido palmitoleico na inflamação hepática; o papel dos ppars.
• Beneficiário: José Cesar Rosa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/09854-9 - O efeito da doxorrubicina sobre o tecido adiposo: elucidando o papel da família dos PPARs
• Beneficiário: José Cesar Rosa Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/24187-6 - Efeitos do exercício físico ao longo da vida e sua relação com a imunidade e o ritmo circadiano
• Beneficiário: Alexandre Abilio de Souza Teixeira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado