The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems

Autor(es)

Fonseca-Santos, Bruno ^[1] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: International Journal of Pharmaceutics; v. 589, NOV 15 2020.
• Citações Web of Science: 2

Resumo

Neurological disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biological activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action and the key points in neurological disorders were described and show the targeted mechanism of action. Due to the insolubility of this compound; the use of nanotechnology-based systems has been proposed for the incorporation of RES and RES-loaded nanocarriers have been designed for intranasal administration, oral or parenteral routes to deliver it to the brain. In general, these nanosystems have shown to be effective in many studies, pharmacological and pharmacokinetic assays, as well as some cell studies. The outcomes show that RES has been reported in human clinical trials for some neurological diseases, although no studies were performed in humans using nanocarriers, animal and/or cellular models have been reported to show good results regarding therapeutics on neurological diseases. Thus, the use of this nutraceutical has shown true for neurological diseases and its loading into nanocarriers displaying good results on the stability, delivery and targeting to the brain. (AU)

• Processo FAPESP: 15/05394-2 - Avaliação do potencial de sistemas nanoestruturados baseados em tensoativos para administração nasal de trans-resveratrol na otimização da terapia da Doença de Alzheimer
• Beneficiário: Bruno da Fonseca dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/19568-4 - Avaliação do potencial de sistemas lipídicos nanoestruturados para administração cutânea de trans-resveratrol
• Beneficiário: Marlus Chorilli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/24180-0 - Sistemas líquido-cristalinos como potencial estratégia para incorporação do trans-resveratrol: desenvolvimento, caracterização físico-química e ensaios biológicos in vitro e in vivo
• Beneficiário: Marlus Chorilli
• Modalidade de apoio: Auxílio à Pesquisa - Regular